Yazar "Duymaz, Tomris" seçeneğine göre listele

Listeleniyor 1 - 20 / 37
  • Küçük Resim
    Öğe
    Acute treatment of ankle ligament injuries: Is kinesio tape effective?
    (Bayrakol Medical Publisher, 2020) Duymaz, Tomris; Yüksel, Serdar
    Aim: This study aimed to compare the efficacy of Kinesio taping (KT) and splinting performed on patients with acute ankle ligament injuries on edema, pain, range of motion and disability. Materials and Methods: This study included 240 patients with an acute ankle sprain. The patients were randomized and divided into two groups each comprising 120 patients. Tape and splint were kept on the patients for 5 days. The following parameters were evaluated before and after treatment: circumference measurement for severity of edema (metatarsophalangeal joint, ankle circumference, 5cm above the ankle, 10cm above the ankle), visual analog scale (VAS) pain score, range of motion(ROM) for the ankle and disability level via the Foot Function Index(FFI). Results: The mean age was 31.10 +/- 11.67 years. When the pain and ROM evaluations were compared between the groups, the patients in the KT group had significantly higher improvement in their pain and ROM compared to the splinting group after treatment (p=0.002, 0.015, 0.523, 0.022, 0.017). The disability levels of the patients treated with KT were significantly improved (p<0.001) at the end of the treatment, but there was no change in patients treated with splinting (p<0.068). According to circumference measurements, the measurement of thickness decreased at all measurement levels in the KT group, whereas the splinting group only showed a decrease in the measurement of circumference at 10 cm above the ankle (p=0.001, <0.001, <0.001, 0.001; 0.059, 0.732, 0.238, 0.014). Discussion: KT is considered to be a treatment modality that contributes to fast recovery and healing, which allows patients to mobilise early, doesn't prevent daily activities such as dressing or taking baths, and increases proprioception and stabilization in the applied area through an increase in sensorial input.
  • Küçük Resim
    Öğe
    Assessing the Clinical Impact of Lutetium-177 DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) on Metastatic Neuroendocrine Tumors: A Multicenter Real-World Data from Türkiye
    (2023) Ünal, Çağlar; Seçuk, Nalan Alan; Duymaz, Tomris
    Objectives: This study aimed to evaluate the clinical outcomes, including progression-free survival (PFS), overall sur-vival (OS), Objective Response Rate (ORR), and Disease Control Rate (DCR), in patients received Lutetium-177 (Lu-177) DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) for metastatic neuroendocrine tumors. This study further stratified outcomes based on tumor grade, Ki-67 status, primary tumor localization, number of treatment cycles, and associated adverse effects.Methods: We conducted a multicenter retrospective study analyzing the data of 73 patients with metastatic NETs across 17 different hospitals in various regions of Turkiye. A total of 73 metastatic NET patients underwent Lu-177 DOT-ATATE PRRT between December 2013 and March 2023. Results: Over a median follow-up of 52.7 months, patients showed a median PFS of 13.7 months and OS of 51.2 months. The ORR was 29.6%, and the DCR was 66.2%. Grade 1 and 2 tumor patients had superior outcomes (PFS: 16.9 months, OS: 55.5 months) compared to grade 3 tumor patients (PFS: 8.5 months, OS: 29.5 months). Based on their Ki-67 status, those <= 20% had prolonged PFS (16.9 months) and OS (55.5 months) than those between 21 and 55% (PFS: 5.9 months, OS: 41.3 months). Regarding primary tumor localization, the PFS values were 13.1, 15.3, 13.7, and 8.6 months for pancreatic, GIS, lung, and unknown origin tumors, respectively. The OS across tumor types fluctuated between 41.1 and 54.1 months. Patients who received more than four cycles demonstrated significantly improved median PFS (22.4 months) and OS (90.3 months) compared to those who received <= 4 cycles (median PFS: 9.3 months; median OS: 41.8 months). Grade 3-4 adverse effects were observed in 21.9% of patients.Conclusion: Our findings affirm that PRRT is a potent and well-tolerated treatment for metastatic NETs. Notably, pa-tients who received more than 4 cycles of PRRT experienced a markedly improved median PFS and OS compared to their counterparts who received <= 4 cycles.
  • Küçük Resim
    Öğe
    Assessment High-Risk Breast Cancer in Older Patients: A Comparative Analysis of PREDICT Scores and TAILORx Risk Categorization
    (GALENOS PUBL HOUSE, 2023-10) Ünal, Çağlar; Özmen, Tolga; Duymaz, Tomris
    Objective: This study aimed to evaluate the relationship between PREDICT tool overall survival (OS) scores and high-risk patients according to TAILORx risk categorization in elderly hormone reseptor (HR) positive human epidermal growth factor negative early breast-cancer patients. Materials and Methods: We conducted a retrospective study, extracting data from medical records of 64 patients diagnosed with breast cancer. A retrospective analysis was performed on all patients who had Oncotype Dx Recurrence Scores across five medical centers between 2017 and 2022. PREDICT scores were defined as calculated 10-year OS rates via PREDICT tool. Results: The median age of the patients was 67, with a range between 65-75 years. Low-risk patients had a slightly higher two PREDICT scores compared to high-risk patients (78% vs. 73%), (81% vs. 77%), which were statistically significant. The progesterone receptor (PR) level was significantly lower in the high-risk group (3.5% vs. 80%). A unit decrease in the PREDICT scores was associated with a 11% increase in the odds of being in the high-risk group. However, these effects weren't statistically significant in the multivariate analysis. A unit decrease in the PR level was significantly associated with increased odds (by 5% in the multivariate analysis) of being in the high-risk group. Conclusion: Our study underscores the importance of using a combination of tools, including the PREDICT tool, PR levels, and TAILORx risk categorization, for a comprehensive risk assessment in these patients, especially in the older population. Accurate risk assessment is crucial for tailoring the treatment and optimizing outcomes in this vulnerable population. Future studies are warranted to further validate these findings in larger cohorts and to explore additional biomarkers and genomic signatures that may aid in the risk assessment and management of breast cancer in older patients.
  • Küçük Resim
    Öğe
    Comparison of physical activity level with sleep quality in premenopausal and postmenopausal women
    (2019) Duymaz, Tomris
    [Abstract Not Available]
  • Küçük Resim
    Öğe
    Comparison of physical activity level with sleep quality in premenopausal and postmenopausal women Physical activity and sleep quality in menopause
    (Bayrakol Medical Publisher, 2019-11) Duymaz, Tomris
    Aim: The aim of this study was to examine the individual and combined associations of physical activity and sleep in premenopausal and postmenopausal women. Material and Method: Two hundred and fifty premenopausal (mean age: 45.50 +/- 2.10) and 250 postmenopausal (mean age: 60.27 +/- 3.03) women were evaluated. We compared age, body mass index (BMI), education, marital status, menopause age, jobs, medical conditions, smoking, physical activity and sleep quality using the Women's Health Initiative Insomnia Rating Scale between groups. The SPSS 22.0 program was used for thre statistical analysis of the research data. Frequency and percentage (average, standard deviation) were used as descriptive statistics of the study. Non-parametric tests (Mann-Whitney U, Kruskal-Wallis, Spearman correlation test) were performed for comparison of the variables, which did not comply with the normal distribution. Significance was accepted as p<0.05. Results: Sleep quality scores were better in premenopausal women when compared with postmenopausal women (p<0.000). No significant differences were found in BMI (p=0.691). The mean menopause age was 47.56 +/- 4.91 in postmenopausal women. Postmenopausal women's physical activity and sleep quality was worse than in premenopausal women. Thirty-four premenopausal (14 of them walking, 8 of them swimming, 12 of them fitness) and 12 postmenopausal (8 of them walking, 4 of them swimming) women had physical activity. In all women, exercise training participants had better sleep quality. Those who exercised had better sleep quality in both groups (p<0.000). No significant differences were found in sleep quality between those premenopausal and postmenopausal women who exercised. Discussion: Objective sleep measures differed significantly between the pre- and postmenopausal groups. These findings provide strong evidence that sleep qualities are more favorable in highly active women relative to less active women.
  • Küçük Resim
    Öğe
    Comparison of Radial Extracorporeal Shock Wave Therapy and Traditional Physiotherapy in Rotator Cuff Calcific Tendinitis Treatment
    (TURKISH LEAGUE AGAINST RHEUMATISM, 2019-09) Duymaz, Tomris; Sindel, Dilşad
    Objectives: This study aims to investigate the efficacy of radial extracorporeal shock wave therapy (rESWT) in relieving pain and improving range of motion (ROM) and functionality besides conventional physiotherapy methods in the treatment of chronic rotator cuff calcific tendinitis (RCCT). Patients and methods: We studied 80 patients (35 males, 45 females; mean age 53.3 +/- 9.6 years; range, 40 to 70 years) with chronic RCCT. Patients were randomly divided into two groups: rESWT group (n=40) treated with conventional physiotherapy and rESWT, and control group (n=40) treated only with a conventional physiotherapy program. The traditional physiotherapy program included ultrasound, transcutaneous electrical nerve stimulation, shoulder joint ROM and stretching exercises, and ice applications. All patients received a total of 20 treatments, five days a week for four weeks. rESWT was applied once a week for four weeks in total. Before and after treatment, all patients were evaluated for age, height, weight, body mass index (BMI), pain intensity with a visual analog scale, shoulder ROM, and functional disability status with the shortened version of the Disabilities of the Arm, Shoulder and Hand questionnaire (QuickDASH). Results: Mean BMI value of the participants was 26.1 +/- 3.0 kg/m(2). Although all parameters of the patients in both groups improved significantly, patients in the rESWT group had a statistically significant improvement in pain, ROM and QuickDash scores (p<0.001, p<0.001, and p<0.001, respectively). Conclusion: We assume that rESWT is an effective and noninvasive method of reducing pain and increasing ROM and functional status without the need for surgery.
  • Küçük Resim Yok
    Öğe
  • Küçük Resim Yok
    Öğe
    Diz Osteoartritli Hastalarda Eklem İçi Viskosuplement Enjeksiyonunun İzokinetik Kas Gücü Üzerine Etkileri
    (2021) Duymaz, Tomris; Ünal, Mehmet; Hakan, Mehmet Tolgahan; Ural, İbrahim Halil
    GİRİŞ ve AMAÇ: Diz osteoartriti hayat kalitesini önemli derecede etkileyen yaygın bir hastalıktır. Rehabilitasyon protokolleri diz eklemi üzerindeki yükü azaltmak amacıyla kas güçlendirme egzersizleri içermelidir. bu çalışmada intraartiküler olarak uygulanan hyaluronik asit, kondroitin sülfat ve glukozamin içeren viskosuplementasyon enjeksiyonlarının diz kaslarının izokinetik kuvvetleri üzerindeki etkilerini araştırdık. YÖNTEM ve GEREÇLER: Çift-kör ve randomize yapılan bu çalışmada demografik veriler ve izokinetik kas gücü ölçümü Biodex (System 3) ile yapıldı. Enjeksiyondan önce ve 3 ay sonra kuadriseps kasının 60°/sn ve 240°/sn açısal hızlarında izokinetik kas gücü testi uygulandı. SPSS for Windows programı ile istatistiksel analizler yapıldı. BULGULAR: 60°/sn ve 240°/sn açısal hızlarında yapılan izokinetik testlerde istatistiksel olarak anlamlı fark bulundu. Diz osteoartriti tedavisinde hyaluronik asit, kondroitin sülfat ve glukozamin içeren viskosuplementasyon enjeksiyonlarının kuadriseps ve hamstring kaslarında total ve fonksiyonel izokinetik kas gücünü arttırdığı saptandı. TARTIŞMA ve SONUÇ: Hyaluronik asit, kondroitin sülfat ve glukozamin içeren viskosuplementasyon enjeksiyonları kuadriseps ve hamstring kaslarında 60°/sn ve 240°/sn açısal hızlarında izokinetik kas gücünün artmasını sağlamaktadır. Tedavi protokollerinde daha fazla yer alabileceği düşünülebilir.
  • Küçük Resim
    Öğe
    Effect of Fear of Covid-19 Infection on Functionality in Breast Cancer Patients in the Pandemic
    (ZAMENSALAMATI PUBL CO, 2022-02) Duymaz, Tomris
    Abstract: Background: Coronavirus disease 2019 (COVID-19) has spread rapidly across the globe through coughing, sneezing, droplet inhalation, and contact.Objectives:The current studyaimedto assess the impact of the fear of COVID-19 infection on functionality in women with breast cancer.Methods:The present study included women with diagnosed breast cancer (n=75) under treatment in Istanbul Florence Nightingale Hospital and healthy (n=69) women( a total of 144 volunteers). The participants were asked to fill out the Sociodemographic Data Form, Anxiety Sensitivity Index-3 (ASI-3), and FearofCOVID-19Scale to evaluate the impact of fear of infection and cleaning behavior due to COVID-19 on functionality.Results: No statistically significant difference was found betweenthe women with and without diagnosed breast cancer regarding the impact of fear of COVID-19 infection on all functionality parameters (all parameters: P>0.05). In the breast cancer group, the effect of Covid-15 anxiety and cleaning behavior on functionality performance was significantly higher in participants with underlying disease (P=0.044, P=0.013)and smoking (P=0.0234, P=0.0147).Conclusion:As evidenced by the results of this study, smoking and the presence of comorbidity in breast cancer patients may have a negative effect on the functionality effect of fearof Covid-19 infection. In terms of psychiatric intervention, the parameters affected by functionality should be considered
  • Küçük Resim Yok
    Öğe
    Effect of Neuromuscular Electrical Stimulation on Functional Mobility in Children with Hemiplegic Cerebral Palsy
    (Galenos Yayincilik, 2018) Duymaz, Tomris
    INTRODUCTION: Ankle deformities are frequently seen in children with cerebral palsy (CP) and affect the functioning of children negatively. The purpose of this study was to investigate the effect of electrical stimulation on the range of motion and functional mobility of movements of tibialis anterior, peroneus longus and peroneus brevis muscles in children with hemiplegic spastic type CP. METHODS: A total of 40 hemiplegic spastic type CP children between 5 and 15 years of age were included in the study. Children are randomly divided into 2 groups. Neurodevelopmental therapy and neuromuscular electrical stimulation (NMES) was applied to the treatment group (n=20), only neurodevelopmental therapy was applied to the control group (n=20). A total 36 treatments were administered for 12 weeks, with 3 treatment sessions per week. After recording the age, body mass index, and gross motor function levels of the children, motor functional levels with the Gross Motor Function Scale (GMFM-88), ankle range of motion with goniometer, functional mobility skills with timed up and go test, timed stairs up and down test were evaluated. Statistical analysis was done by SPSS 22.0 program and significance was accepted as p < 0.05. RESULTS: The average age of the children participating in the study was 8.30 +/- 2.49 years. Comparisons between groups before and after treatment showed statistically significant improvement in range of active dorsi flexion, timed up and go test, and timed stairs up and down test in the treatment group (p=0.033, 0.015, 0.036). DISCUSSION and CONCLUSION: NMES therapy has been identified as a method that strengthens the weak muscles of children with hemiplegic CP, relaxes them by creating stretching effects on spastic muscles, and normalizes muscle imbalance, thereby increasing gross motor functions, walking ability, and functional ability.
  • Küçük Resim
    Öğe
    Effect of physiotherapy on respiratory functions in patients with chronic neck pain
    (2019) Duymaz, Tomris
    [Abstract Not Available]
  • Küçük Resim
    Öğe
    Effect of physiotherapy on respiratory functions in patients with chronic neck pain Physiotherapy on respiratory functions of neck pain
    (Bayrakol Medical Publisher, 2019-11) Duymaz, Tomris
    Aim: The aim of this study was to investigate the effects of physiotherapy methods applied for chronic neck pain treatment on pulmonary function, functional capacity, pain, and disability. Material and Method: This is a randomized controlled prospective study conducted in 84 patients with chronic neck pain. Patients were divided into 2 groups and physiotherapy was performed in 42 patients (10 minutes with ultrasound 1.0W/cm2 intensity, 20 minutes with conventional Transcutaneous Electrical Nerve Stimulation, 20 minutes with hot pack), home exercise program, respiratory exercises; and 42 patients in the control group had only home exercise and breathing exercises. Age, body mass index (BMI), duration of pain, severity and frequency of pain were recorded in all patients before treatment. Then, at the beginning and at the end of the treatment, pain intensity was assessed by visual analog scale (activity, rest, night), functional capacities with 6-minute walking test (6MWT), respiratory function tests with a spirometer, and disability with neck disability index (NDI) were assessed. Statistical analysis was performed with SPSS 22.0 program and p<0.05 was considered significant. Results: The mean age of the patients was 42.40 +/- 7.26 years and mean pain duration was 18.47 +/- 13.49 months. VAS,6MWT,NDI and VC, ERV(expiratory reserve volume), TV(tidal volume), FEV1(forced expiratory volume in 1 second), FEV1 / FVC, FEF25-75(forced expiratory flow at 25-75%) were found to have a significant improvement in the treatment group in intra- and intergroup comparisons (p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, 0.024, 0.057, p<0.001, 0.009, p<0.001, 0.006). In the control group, the only significant improvement was observed in intra-group VAS values, p=0.015, 0.020, 0.034). Discussion: Physiotherapy program applied to patients with chronic neck pain has been found to increase respiratory functions and functional capacity with decreasing pain and disability level.
  • Küçük Resim Yok
    Öğe
    Effectiveness of kinesio taping in bicipital tendinitis treatment: A randomized controlled trial
    (Bayrakol Medical Publisher, 2020) Genc, Erdinc; Duymaz, Tomris
    Aim: Biceps tendinitis is characterized by inflammation of the biceps long head, and treatment options include various conservative and surgical methods. Kinesiotaping (KT) has benefited in reducing pain and providing motor control in various shoulder disorders. The aim of this study is to investigate the effectiveness of KT application in patients with biceps tendinitis in terms of pain, pain threshold, upper extremity functionality level and quality of life. Materials and Methods: Eighty patients with biceps tendinitis were divided into two groups randomly, each comprising 40 patients. The study group received KT with an exercise program, the control group received an exercise program only. Pre- and post-treatment evaluations were conducted. Pain threshold was evaluated with a digital algometer, pain severity with visual analog scale (VAS), functional capacity with the disabilities of the arm, shoulder and hand score (Q-DASH) and quality of life with Nottingham Health Profile (NHP). Results: The mean duration of the symptoms was 4.5 months and the mean age was 45.80 +/- 8.48 years. Pain intensity decreased during activity (p<0.001) and pain thresholds increased (p<0.001) in the KT group. Q-DASH scores improved significantly in patients in the KT group, there was a less significance in the control group (p<0.001, 0.043). The NHP scores except social isolation improved in all sub-parameters of the KT group and there was no significance in control group (p>0.05, 0.003, 0.012, 0.023, 0.225, 0.035, 0.029, 0.006). Discussion: KT application decreases pain and increases the functional capacity level and can also play a role in improving the general quality of life in biceps tendinitis treatment.
  • Küçük Resim
    Öğe
    Effectiveness of the mulligan mobilization technique in mechanical neck pain
    (2018) Duymaz, Tomris; Yağcı, Nesrin
    Aim: The aim of this study was to investigate the effectiveness of Mulligan Mobilization technique in participants with mechanical neck pain. Material and Method: A total of 40 participants (35 female, 5 male) aged between 25 to 50 years were included the study. Participants were randomly divided into two groups as Mulligan Mobilization group and control group. The participants in both groups received home exercise program. The participants were treated 10 times for two weeks. Pain (Visual Analog Scale), muscle strength (stabilizer pressure biofeedback, Hand Held Dynamometer), range of motion (universal goniometer) pain threshold (algometer), disability level (Neck Disability Index), quality of life (Nottingham Health Profile), depressive symptoms (Beck Depression Inventory), cervical performance level (cervical performance tests) were measured at baseline, after the treatment program and repeated 1 month and 3 months after the end of the treatment. Results: In both groups' pain intensity, pain threshold, musde strength, performance level, the range of motion, disability, depression, and quality of life improved after the treatment program (p<0.05). Discussion: The results of this study showed Mulligan Mobilization treatment program has positive effects on pain, the range of motion, muscle strength, performance level, disability, depressive symptoms, and quality of life in participants with mechanical neck pain.
  • Küçük Resim
    Öğe
    Effects of nutrition and exercise habits in patients with type 2 diabetes
    (European Journal of Therapeutics, 2018) Duymaz, Tomris
    ABSTRACT: Objective: Diet and exercise therapy form the basis of treatment of type 2 diabetes mellitus (T2DM). The objective of the present study was to evaluate the effects of diet and physical activity interventions for patients with T2DM. Methods: We assessed the prospective association between levels of physical activity, diet, and quality of life (QOL) in patients with T2DM. We measured body mass index (BMI), waist-to-hip ratio, and QOL index (36-item Short Form Health Survey). A total of 300 patients (169 women and 131 men) were enrolled in the study. Results: The mean age and BMI of the patients were 53.50±8.58 years, 30.39±3.97 kg/m2 in women and 56.32±8.80 years, 30.28±1.79 kg/m2 in men, respectively. QOL was significantly increased in patients with T2DM with regular exercise and diet (p=0.001, 0.024, and 0.012). Conclusion: Our findings show that combined diet and physical activity interventions achieved clinically meaningful increase in the QOL. Especially, aerobic exercise program improved the QOL in women with T2DM.
  • Küçük Resim Yok
    Öğe
    Effects of the Three-Dimensional Vision System on Surgical Performance, Muscular Fatigue, and Pain During Urologic Laparoscopic Tasks: Results of Objective Assessments and a Mini Questionnaire Survey
    (Mary Ann Liebert, Inc, 2019) Aykan, Serdar; Temiz, Mustafa Zafer; Duymaz, Tomris; Ural, Ibrahim Halil; Colakerol, Aykut; Muslumanoglu, Ahmet Yaser; Semercioz, Atilla
    Background: The three-dimensional (3D) vision system was released to the medical market to improve laparoscopic outcomes. We analyzed the muscular pain and fatigue, and the performance outcomes after several laparoscopic urologic tasks were completed with the 3D vision system. Methods: A total of 49 participants with different surgical expertise levels were enrolled in the study. All the participants performed some laparoscopic urologic tasks using two-dimensional (2D) and 3D vision systems separately. A mini questionnaire survey was also completed by the participants. The duration and quality of the tasks and the muscular fatigue and pain were objectively determined. All the parameters were compared between the 2D and 3D systems. Results: Although all the tasks were completed in significantly shorter times with the 3D vision system in each expertise level, maximal shortening was seen in the residents. The overall quality scores were significantly higher with the 3D vision system. However, a maximal increase was seen in the residents. The muscular pain of the participants was lower with 3D vision system. The overall handgrip strength significantly increased from 41.2 to 42.4kg after the tasks with the 3D vision system, but the difference was significant in only the residents. Twenty-seven participants (56.2%) declared that the 3D system contributed to their performance, and most of the participants (83.3%) preferred the 3D system in the questionnaire survey. Conclusion: 3D technology may be effective for use in urologic laparoscopic training programs of novice surgeons. It may also contribute to the skills of specialists and experts, shortening the surgical time, which may decrease the surgical morbidity.
  • Küçük Resim Yok
    Öğe
    Efficacy of kinesio taping on pain, pain threshold and emotional status in tension-type headache
    (Edizioni Minerva Medica, 2021) Duymaz, Tomris
    BACKGROUND: One of the most important sources of pain in tension-type headache(TTH) is myofascial tissues. For this reason, there is a direct relationship between the sensitivity of the muscles and the presence of TTH. The purpose of this study was to investigate the efficacy of Kinesiotaping (KT) on upper trapezius muscle on the reduction of pain and emotional state in the treatment of patients with WITH by acting on myofacial mechanoreceptors. METHODS: This study was conducted in 271 patients aged 30-45 years with TTH diagnosed. Patients were randomly divided into 2 groups. While KT and stretching exercises were performed in the study group, only the stretching exercise was performed for the control group. KT was applied 8 times in total for 4 weeks with 2 sessions per week. Stretching exercise was done in the morning, afternoon and evening 3 times every day for 4 weeks and 5 days of the week. After recording the demographic data of all the patients participating in the study, assessed the sensitivity of the right and left upper parts of the trapezius with algometer, pain intensity with visual analog scale(VAS).Beck depression and anxiety scale for emotional status before and after treatment. P<0.05 was considered statistically significant. RESULTS: Pain severities of the patients, pain thresholds of the trapezius muscle and depression and anxiety levels showed a statistically more significant improvement in the KT group than in the control group (P=0.005, <0.001, <0.001,0.010). CONCLUSIONS: It has been determined that KT combined with stretching exercise reduces pain severity, increases pain pressure thresholds, and also improves depression and anxiety symptoms in TTH.
  • Küçük Resim
    Öğe
    Erythrocytic Reduced/Oxidized Glutathione and Serum Thiol/Disulfide Homeostasis in Patients with Opioid Use Disorder
    (AVES, 2023-12-03) Şahin, Esra Kabadayı; Senat, Almila; Söğüt, İbrahim; Duymaz, Tomris; Erel, Özcan
    Background: This study aimed to evaluate oxidative damage by measuring erythrocytic reduced/oxidized glutathione as an intracellular thiol pool and serum thiol/disulfide homeostasis as an extracellular thiol pool in patients with opioid use disorder. Methods: In this prospective cross-sectional study, 33 male patients diagnosed with opioid use disorder and 30 healthy male controls were included. Sociodemographic characteristics and psychometric analyzes were performed and addiction characteristics (duration and amount of heroin use, usage methods) were recorded. For the evaluation of oxidative balance, intracellular reduced-oxidized glutathione (reduced glutathione and oxidized glutathione), and extracellular thiol-disulfide (native thiol and disulfide) levels were measured. Results: There was a decrease in reduced glutathione and native thiol levels and an increase in GSSG and SS levels. Similarly, while oxidized/reduced glutathione, oxidized/total glutathione%, and disulfide/native thiol % ratios increased, the ratio of reduced glutathione/total glutathione% and native thiol/total thiol% decreased. Moreover, a positive correlation was found between the level of both intracellular and extracellular oxidant molecules and the duration and amount of opioid use. Conclusion: Impaired intracellular reduced glutathione/oxidized glutathione and extracellular disulfide/native thiol homeostasis were found in patients with opioid use disorder. The intracellular and extracellular oxidative stress may cause complications related to chronic opioid use.
  • Küçük Resim
    Öğe
    Evaluation of Anti-Mullerian Hormone Levels, Antral Follicle Counts, and Mean Ovarian Volumes in Chemotherapy-Induced Amenorrhea among Breast Cancer Patients: A Prospective Clinical Study
    (MDPI, 2023-10) Ünal, Çağlar; Özmen, Tolga; Duymaz, Tomris
    Estradiol (E2), a follicle-stimulating hormone (FSH), AMH, and inhibin B levels, along with AFC and MOV, are used to determine ovarian reserve in pre-menopausal women. Studies have shown that AMH levels are more sensitive than those of E2, FSH, and inhibin B and that AFC and MOV can be used to evaluate ovarian reserve. AMH, AFC, and MOV measurements were performed before and after adjuvant SC in 3-month periods for one year. Patients were classified as experiencing chemotherapy-induced amenorrhea (CIA) if they did not have menstrual cycles for a period of six months or longer following the conclusion of their chemotherapy treatment. We aimed to evaluate the factors affecting chemotherapy-induced amenorrhea in breast cancer patients treated with adjuvant chemotherapy and the performance of baseline measurements of AMH, AFC, and MOV to predict chemotherapy-induced amenorrhea. The effects of different chemotherapy regimens on the AMH level, AFC, and MOV in CIA patients were investigated. Seventy-one patients were eligible for this study, and the median age was 38 years (range: 23–45). The median follow-up was 37 months (range: 20–51), and CIA developed in 62% of the patients. The AMH level and AFC were significantly decreased one year after SC (p < 0.0001), whereas MOV was not (p = 0.507). AMH levels before chemotherapy (median: 1.520 vs. 0.755, p = 0.001) and at the end of the first year (median: 0.073 vs. 0.010, p = 0.030) and pre-treatment AFC (median: 12 vs. 4.50, p = 0.026) were lower in patients with CIA compared to those without CIA. The AMH levels before SC were the most valuable and earliest factor for predicting CIA development. In addition, there was no difference between the chemotherapy regimens (including or not including taxane) in terms of CIA development.
  • Küçük Resim
    Öğe
    Evaluation of Atherosclerotic Risk by Oxidative Contributors in Alcohol Use Disorder
    (KOREAN COLL NEUROPSYCHOPHARMACOLOGY, 2023-08) Senat, Almila; Şahin Kabadayı, Esra; Söğüt, İbrahim; Duymaz, Tomris; Özcan, Erel
    Objective: Alcohol Use Disorder (AUD) is a condition described as the inability to control or stop alcohol consumption. The patients with AUD have an increased risk of developing atherosclerosis-related diseases. The present study aimed to evaluate oxidative contributors of atherosclerotic risk factors in patients with AUD.Methods: The male subjects diagnosed with AUD (n = 45) and the male subjects as control (n = 35) were enrolled in this study. All participants were undergone psychiatric evaluation and sociodemographic tests. Also, serum oxidative contributors of atherosclerosis including myeloperoxidase (MPO), ferroxidase, catalase (CAT), and lipid hydroperoxides (LOOH) were measured. Additionally, serum lipid profile tests and atherogenic indicators including atherogenic index of plasma (AIP) and non-high-density lipoprotein (HDL) cholesterol were also analyzed.Results: The AUD subject had significantly elevated MPO activity and LOOH levels with decreased antioxidant capacity. AIP and non-HDL cholesterol levels, the atherogenic indicators, were also higher in AUD group compared to the control group. We found the MPO activity and LOOH levels were positively correlated with AIP, non-HDL cholesterol levels, and amount of alcohol consumption. Additionally, CAT activity was negatively correlated with duration of alcohol consumption. Conclusion: Our results revealed that MPO and LOOH levels were elevated by severe alcohol intake and the athero-genic indicators, AIP and non-HDL cholesterol, were significantly correlated alcohol induced elevated oxidative risk factors. Therefore, it can be suggested that MPO activity and LOOH levels may be useful to determine jeopardy of atherosclerotic and the therapeutic interventions that reduce oxidative load could be taken into account to prevent atherosclerotic diseases before clinical manifestation.