The Relationship of Pathological Response and Visceral Muscle and Fat Volume in Women With Breast Cancer Who Received Neoadjuvant Chemotherapy

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dc.authorscopusid59002225500
dc.authorscopusid56522791700
dc.authorscopusid57210288465
dc.authorscopusid35268079300
dc.authorscopusid26026591400
dc.authorscopusid35608451600
dc.authorscopusid35095972600
dc.contributor.authorTapan, T.K.
dc.contributor.authorÇelebi, F.
dc.contributor.authorYaghouti, K.
dc.contributor.authorAğaçayak, F.
dc.contributor.authorIlgün, S.
dc.contributor.authorSoybir, G.
dc.contributor.authorAlço, G.
dc.date.accessioned2024-07-18T20:17:30Z
dc.date.available2024-07-18T20:17:30Z
dc.date.issued2024
dc.description.abstractObjective: Differences in individual muscle/fat volumes may change the effectiveness of chemotherapy. In this study, the relationship between trunkal muscle and fat volume and body mass index (BMI) obtained before receiving neoadjuvant chemotherapy (NCT) in patients with breast cancer and complete pathological response (pCR) was investigated. Materials and Methods: The volumes of psoas, abdominal and paraspinal muscles, and trunkal subcutaneous and visceral fat were calculated using CoreSlicer AI 2.0 opensource program from the F-18 fluorodeoxyglucose positron emission tomography/computed tomography (CT) and CT images before NCT and postoperative pCR rates to NCT were recorded. Muscle/fat volumes and BMI prior to NCT were compared in terms of pathological pCR rates. Patients were followed up regularly for recurrence and survival. Results: Ninety-three patients were included with median (range) values for age, BMI, and body weights of 48 (28-72) years, 27 (16.8-51.6) kg/m2, and 71.94 (43-137) kg, respectively. The median follow-up time was 18.6 (6.7-59.6) months. No significant correlation was found between total muscle or fat volumes of patients with and without pCR. BMI [26.2 (16.8-51.6) kg/m2 vs. 24.6 (20.3-34.3) kg/m2, p = 0.03] and pCR rates in patients with low rightpsoas muscle volume [11.74 (7.03-18.51) vs. 10.2 (6.71-13.36), p = 0.025] were significantly greater. A significant relationship was found between right psoas muscle volume and disease-free survival (DFS) (11.74 cm3 (7.03-18.51) vs. 10.2 cm3 (6.71-13.36), p = 0.025). However, no significant relationship was detected between total muscle-fat volume, BMI and overall survival and DFS (p>0.05). Conclusion: This is the first published study investigating the relationship between the pCR ratio and body muscle and fat volume measured by CoreSlicer AI 2.0 in patients with breast cancer who received NCT. No correlation was found between the pCR ratio and total muscle plus fat volume. However, these results need to be validated with larger patient series. © 2024 by the Turkish Federation of Breast Diseases Societies.en_US
dc.identifier.doi10.4274/ejbh.galenos.2024.2023-12-5
dc.identifier.endpage121en_US
dc.identifier.issn2587-0831
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85191318043en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.4274/ejbh.galenos.2024.2023-12-5
dc.identifier.urihttps://hdl.handle.net/11411/6592
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publishing Houseen_US
dc.relation.ispartofEuropean Journal of Breast Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBmıen_US
dc.subjectBreast Canceren_US
dc.subjectFdg-Pet-Cten_US
dc.subjectNeoadjuvant Chemotherapyen_US
dc.subjectPcren_US
dc.subjectTotal Muscle-Fat Volumeen_US
dc.titleThe Relationship of Pathological Response and Visceral Muscle and Fat Volume in Women With Breast Cancer Who Received Neoadjuvant Chemotherapy
dc.typeArticle

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