Factors related to restless leg syndrome in neuromyelitis optica spectrum disorder

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dc.authorid0000-0003-0043-9374
dc.contributor.authorOzdogar, Asiye Tuba
dc.contributor.authorKarakas, Hilal
dc.contributor.authorDastan, Seda
dc.contributor.authorKaya, Ergi
dc.contributor.authorSagici, Ozge
dc.contributor.authorOzcelik, Sinem
dc.contributor.authorOzakbas, Serkan
dc.date.accessioned2026-04-04T18:55:35Z
dc.date.available2026-04-04T18:55:35Z
dc.date.issued2025
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractObjective: Although the feeling of unrest in the legs is frequently reported as a sensory symptom by people with Neuromyelitis Optica Spectrum Disorder (NMOSD, pwNMOSD), there are limited studies to investigate the relationship between Restless Legs Syndrome (RLS) and NMOSD. The study's primary aim is to determine the frequency and severity of RLS in pwNMOSD. The other aim is to compare the sleep quality, daytime sleepiness level, quality of life, fatigue, magnetic resonance imaging results, and cognitive functions in RLS-positive and negative pwNMOSD. Methods: The RLS diagnosis was performed with RLS-Diagnostic Index criteria. The patient-reported outcomes were RLS Severity Rating Score, The Preference-Based Multiple Sclerosis Index (PBMSI), the Modified Fatigue Impact Scale (MFIS), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). Cognitive function was assessed with The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery. The neurologist recorded the demographic and clinical characteristics of the participants. Results: The RLS was detected in 17 (21.5 %) of the 79 pwNMOSD participants. Fifty-six pwNMOSD were reached to assess cognitive functions and patient-reported outcomes. The rate of RLS was 60.71 % in this group. The PBMSI, PSQI, MFIS, and ESS scores were significantly different in RLS-positive participants than in RLS-negative (p < 0.05). Moreover, while participants' visuospatial and verbal learning was similar, the processing speed was slow in the RLS-positive group (p > 0.05). Conclusions: Our preliminary results have shown that the RLS frequency is high in pwNMOSD. This study suggests a connection between the presence of RLS and worse sleep quality, fatigue level, processing speed, and quality of life in the NMOSD population. However, our results should be considered with the fact that the study has a small sample size and needs future studies to confirm our results for solid evidence.
dc.identifier.doi10.1016/j.msard.2025.106308
dc.identifier.doi10.1016/j.msard.2025.106308
dc.identifier.issn2211-0348
dc.identifier.issn2211-0356
dc.identifier.pmid39923412
dc.identifier.scopus2-s2.0-85217042559
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.msard.2025.106308
dc.identifier.urihttps://hdl.handle.net/11411/10468
dc.identifier.volume95
dc.identifier.wosWOS:001426444400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofMultiple Sclerosis and Related Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectNeuromyelitis Optica Spectrum Disorder
dc.subjectRestless Legs Syndrome
dc.subjectSleep Quality
dc.subjectFatigue
dc.subjectCognitive Functions
dc.titleFactors related to restless leg syndrome in neuromyelitis optica spectrum disorder
dc.typeArticle

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