Bioactive nano-scale material approved with HepG2 and MCF-7 cancer cell lines, antimicrobial properties and characterization parameters

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dc.authorid0000-0002-2592-6438
dc.authorid0000-0002-0659-3586
dc.contributor.authorCeylan, Zafer
dc.contributor.authorInanli, Ayse Gurel
dc.contributor.authorMeral, Raciye
dc.contributor.authorDalkilic, Semih
dc.contributor.authorDalkilic, Lutfiye Kadioglu
dc.contributor.authorKaraismailoglu, Mehmet Cengiz
dc.contributor.authorKose, Nusret
dc.date.accessioned2026-04-04T18:55:29Z
dc.date.available2026-04-04T18:55:29Z
dc.date.issued2024
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractThe carvacrol nanoemulsion (CNe) was successfully fabricated in the present study. In this regard, the mean particle size (PS) value of the CNe was determined as 321 nm. The zeta potential value of CNe was determined as -54.27 mV while the PDI value of CNe was found as 0.266. With FTIR analysis, the molecular characterization was applied, for example, the peak at 3365 cm(-1) was observed for hydrogen-bonded stretch vibrations of O-H or N-H groups in CNe. The cytotoxic effects of CNe via MCF-7 (88 and 33 % decline in cell viability) and HepG2 (86 and 48 %: decline) were determined. The carvacrol nanoemulsion indicated a high antibacterial effect with 3-9 mu L concentration on the growth of B. cereus with an inhibition zone diameter of 14.3-28.3 mm(-1). The CNe with 0.5-1.5 mL showed bactericidal properties on V. parahaemolyticus with an inhibition zone diameter of 12.6-16.3 mm (p < 0.05). With the novel nano-approach, the carvacrol nanoemulsion with anticancer and antimicrobial properties could play a guiding role for further applications with further studies in industry treatments such as food and hygienic procedures.
dc.description.sponsorshipFimath;rat University Scientific Research [SF.21.04]
dc.description.sponsorshipPart of this research was supported by the F & imath;rat University Scientific Research (Grant No: SUF.21.04) . The authors would like to thank the F & imath;rat University, Bartin University, and Van Yuzuncu Y & imath;l University for the use of all facilities.
dc.identifier.doi10.1016/j.fbio.2024.104696
dc.identifier.doi10.1016/j.fbio.2024.104696
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85199002037
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2024.104696
dc.identifier.urihttps://hdl.handle.net/11411/10443
dc.identifier.volume61
dc.identifier.wosWOS:001275000400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofFood Bioscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectBio-Nanomaterial
dc.subjectAntimicrobial
dc.subjectAnticancer
dc.subjectCharacterization
dc.subjectIndustry
dc.titleBioactive nano-scale material approved with HepG2 and MCF-7 cancer cell lines, antimicrobial properties and characterization parameters
dc.typeArticle

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