The Diagnostic Value of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Drug Naive, First Episode, Non-Smoker Generalized Anxiety Disorder Patients

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dc.WoS.categoriesNeurosciences; Pharmacology & Pharmacyen_US
dc.authorid0000-0003-0576-9487en_US
dc.contributor.authorFındıklı, Ebru
dc.contributor.authorSümer, Perihan
dc.contributor.authorCankurt, Mehmet Akif
dc.contributor.authorİzci, Filiz
dc.contributor.authorFındıklı, Hüseyin Avni
dc.contributor.authorKaraaslan, Mehmet Fatih
dc.contributor.authorKurutaş, Ergül Belge
dc.date.accessioned2020-11-24T07:18:47Z
dc.date.available2020-11-24T07:18:47Z
dc.date.issued2018-02
dc.description.abstractObjective: Generalized anxiety disorder (GAD) is a common anxiety disorder. Although lots of research done to reveal neurobiological basis of GAD, it is still unclear. Diagnosis of GAD depends on subjective complaints of patients, thus the need for a biological marker is constantly emerging. In this study, we aimed to investigate diagnostic value of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in GAD. Methods: We evaluated MDA, SOD, and CAT levels in peripheral blood of 46 patients and 45 controls. MDA was measured with Ohkawa's methods, SOD was measured with Fridovich method, and CAT was measured with Beutler's method. Results: MDA was significantly increased in patients than controls, medians 4.05 nmol/mg and 1.71 nmol/mg respectively, p<0.001; SOD and CAT activity was significantly decreased in patients than controls, medians of SOD were 159.07 U/mg and 301.87 U/mg, p<0.001 respectively, medians for CAT were 138.47 U/mg and 160.60 U/mg respectively. We found high correlation between Hamilton Anxiety Rating Scale and SOD, MDA r values were 0.723 and 0.715 respectively, p<0.001 for both. Receiver operator characteristic (ROC) curve analysis showed high diagnostic performance for MDA and SOD, low diagnostic performance for CAT, areas under curve were 1.0, 1.0, and 0.648 respectively. Conclusion: Our results reveal possible diagnostic value of MDA, less likely of SOD but not CAT. Future studies should investigate diagnostic value of oxidants and antioxidantn enzymes in larger samples and include diagnostic value of these parameters.en_US
dc.fullTextLevelFull Texten_US
dc.identifier.doi10.9758/cpn.2018.16.1.88en_US
dc.identifier.issn2093-4327
dc.identifier.issn1738-1088
dc.identifier.pmid29397670en_US
dc.identifier.urihttps://hdl.handle.net/11411/2706
dc.identifier.urihttps://doi.org/10.9758/cpn.2018.16.1.88
dc.identifier.wosWOS:000425540200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.issue1en_US
dc.language.isoenen_US
dc.nationalInternationalen_US
dc.numberofauthors5en_US
dc.pages88-94en_US
dc.publisherKOREAN COLL NEUROPSYCHOPHARMACOLOGYen_US
dc.relation.ispartofCLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMalondialdehydeen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectCatalaseen_US
dc.subjectGeneralised anxiety disorderen_US
dc.subjectOxidativeen_US
dc.subjectBiomarkersen_US
dc.titleThe Diagnostic Value of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Drug Naive, First Episode, Non-Smoker Generalized Anxiety Disorder Patientsen_US
dc.typeArticleen_US
dc.volume16en_US

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