Cost-effective, microstrip antenna driven ring resonator microwave biosensor for biospecific detection of glucose
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Institute of Electrical and Electronics Engineers Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We present a biosensor based on electromagnetic ring resonator for label-free detection of glucose. The sensing mechanism is based on the principle that the resonant frequencies of such structures depend on the structure geometry and the physical properties of the medium they are in, such as electrical permittivity. The sensor in this paper uses a split-ring resonator fabricated on a flame retardant four substrate via simple printed circuit board fabrication techniques. Glucose oxidase enzyme was incorporated in order to provide biospecificity for glucose. Conductive polymer poly(3,4-ethylenedioxythiophene)poly(styrenesulfonate), also known as PEDOT:PSS, was used for the immobilization of the enzyme on sensor surface. The redshift of the resonant frequency of the sensor in response to DI water, glucose, and NaCl solutions are shown to be in agreement with simulation results and theoretical expectations. In the presence of the enzyme, the sensor loaded with a glucose solution was observed to experience a resonant frequency shift of 17.5 MHz in 15 min, whereas other reagents such as fructose, sucrose, and NaCl did not respond significantly, confirming the biospecificity. The sensor was measured to have a sensitivity of 0.107 MHz/mgml-1. © 1995-2012 IEEE.
Açıklama
Anahtar Kelimeler
Biosensors, Glucose, Gox, Metamaterials, Split Ring Resonators, Biosensors, Conducting Polymers, Cost Effectiveness, Enzyme İmmobilization, Glucose, Glucose Sensors, Metamaterials, Microstrip Antennas, Microwave Resonators, Natural Frequencies, Optical Resonators, Printed Circuit Boards, Ring Gages, Sodium Chloride, Substrates, Electrical Permittivity, Fabrication Technique, Label-Free Detection, Poly(Styrene Sulfonate), Poly-3 ,4-Ethylenedioxythiophene, Resonant Frequency Shift, Split Ring Resonator, Structure Geometry, Glucose Oxidase
Kaynak
IEEE Journal of Selected Topics in Quantum Electronics
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
23
Sayı
2
