Dosimetric influence of Flattening Filter (FF) and Flattening Filter Free (FFF) 6 and 10 MV photon beams on Volumetric Modulated Arc Therapy (VMAT) planning in case of prostate carcinoma

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dc.authorwosidSaglam, Esra Kaytan/AAE-7436-2020
dc.contributor.authorCakir, A.
dc.contributor.authorAkgun, Z.
dc.contributor.authorSaglam, E. Kaytan
dc.date.accessioned2024-07-18T20:49:11Z
dc.date.available2024-07-18T20:49:11Z
dc.date.issued2019
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractBackground: In the treatment of prostate cancer, radiotherapy is the potential to increase second primary cancers such as bladder and rectal cancers. The reasons for this potential are more monitor units (MUs), therefore a larger total body dose because of leakage radiation, a bigger volume of normal tissue is exposed to lower radiation doses. This study was designed to compare the integral dose of using Flattening Filter (FF) and Flattening Filter-Free (FFF) 6 and 10 MV photon beams via volumetric modulated arc therapy (VMAT) for prostate cancer patients. Materials and Methods: Twenty prostate cancer patients were selected retrospectively for this planning study. VMAT plans were developed using the Eclipse (Varian Medical System, Palo Alto, California, USA) Treatment Planning System (TPS) with 6 MV FF, 6 MV FFF, 10 MV FF and 10 MV FFF for each patient. Conformity index (CI), homogeneity index (HI), Integral dose (ID), the volume receiving 5 Gy (V5%) and monitor units (MUs) were compared. Results: The use of 10 MV FF had 206 liter*Gy integral dose to Body-CTV volume. Using 10 MV FFF had 204 liter*Gy integral dose to normal structures. When 10 MV FF or 10 MV FFF were used instead of 6 MV FF and 6 MV FFF integral dose decreased as -7% and -8%, respectively. The dosimetric difference were statistically significant (p<0.05). The use of 10 MV FFF rather than 10 MV FF had limited influence on the integral dose for rectum, bladder, penile bulb and femoral heads. Conclusions: This study showed that high energy photons (10 MV FF, 10 MV FFF) have lower integral dose than low energy photons (6 MV FF, 6 MV FFF). The relationship between low energies, high energies and integral doses is significant, although there is no significant relationship between V5% doses of all energies. In comparison to different treatment plans, we showed that V5% alone did not provide enough information when possible secondary cancer risks were calculated.en_US
dc.identifier.doi10.18869/acadpub.ijrr.17.2.253
dc.identifier.endpage263en_US
dc.identifier.issn2322-3243
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85072215551en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://doi.org/10.18869/acadpub.ijrr.17.2.253
dc.identifier.urihttps://hdl.handle.net/11411/8117
dc.identifier.volume17en_US
dc.identifier.wosWOS:000469966100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIjrr-Iranian Journal Radiation Resen_US
dc.relation.ispartofInternational Journal of Radiation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntegral Radiation Doseen_US
dc.subjectSecondary Canceren_US
dc.subjectFlattening Filter Free Beamen_US
dc.subjectVolumetric Modulated Arc Therapyen_US
dc.subjectProstate Canceren_US
dc.subject3-Dimensional Conformal Radiotherapyen_US
dc.subjectRadiation-Therapyen_US
dc.subject2nd Cancersen_US
dc.subjectImrten_US
dc.subjectRisken_US
dc.subjectMalignanciesen_US
dc.subjectTomotherapyen_US
dc.subjectOutcomesen_US
dc.titleDosimetric influence of Flattening Filter (FF) and Flattening Filter Free (FFF) 6 and 10 MV photon beams on Volumetric Modulated Arc Therapy (VMAT) planning in case of prostate carcinoma
dc.typeArticle

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