Using embossing ice particulate method to prepare polyvinyl alcohol/ pullulan hydrogels with surface open pores loaded with microspheres for breast cancer treatment

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dc.authoridNG, YUK YIN/0000-0001-9755-6045|Yilmaz, Bengi/0000-0001-7642-4684
dc.authorwosidNG, YUK YIN/AAG-7977-2020
dc.authorwosidYilmaz, Bengi/V-3011-2019
dc.contributor.authorBarer, Neslihan
dc.contributor.authorTunc, Bugse
dc.contributor.authorYilmaz, Bengi
dc.contributor.authorNg, Yuk Yin
dc.contributor.authorDalgic, Ali Deniz
dc.date.accessioned2024-07-18T20:42:46Z
dc.date.available2024-07-18T20:42:46Z
dc.date.issued2024
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractIn the post -operative treatment of breast cancer, early prevention of locoregional recurrence is crucial to avoid metastasis of cells from leftover microtumor tissues. The limitations in conventional drug delivery systems show a growing clinical demand for disease -specific drug -releasing systems. This study explores a novel poly(vinyl alcohol)/pullulan (PVA/PUL) hydrogel system for local drug delivery in post -operative breast cancer treatment. Hydrogel was produced by combination of lyophilization and embossing ice particulate techniques to create microspheres loaded open pores on the hydrogel surface for localized release of doxorubicin-loaded polycaprolactone microspheres (DOX-PCL-MSs). PVA/PUL hydrogel was successfully crosslinked with glutaraldehyde and stabilized hydrogel structure has possessed slow degradation rate and increasing water retention through 12 days. Release of DOX after 7 and 16 days from DOX-PCL-MSs loaded hydrogels were slower with a 6.2 +/- 8.9 % and 56.6 +/- 4.5 % release compared to 60.9 +/- 14.6 % and 76.8 +/- 19.7 % release from free DOX loaded hydrogel since DOX release was controlled by PCL microspheres. When interacted with human breast cancer cell line (MCF-7), DOX-PCL-MSs were able to disrupt cell and spheroid morphology after 7 days at concentrations as low as 12 mu g/mL loaded DOX. In vitro cytotoxicity study has showed that, DOX-PCL-MSs loaded hydrogel was able to decrease MCF-7 viability after 7 days of incubation with controlled release of DOX. While free DOX releasing hydrogel has lost cytotoxic activity even after 4 days of incubation. Furthermore, ability of PVA/PUL hydrogel to support L929 cell attachment was shown in the study, suggesting hydrogels potential for promoting tissue regeneration after anti -cancer treatment. The study reveals that PVA/PUL hybrid hydrogels loaded with DOXPCL-MSs has impactful potential in post -surgical treatment of breast cancer.en_US
dc.identifier.doi10.1016/j.jddst.2024.105351
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85182549738en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2024.105351
dc.identifier.urihttps://hdl.handle.net/11411/7416
dc.identifier.volume92en_US
dc.identifier.wosWOS:001163578500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectLocal Deliveryen_US
dc.subjectPost -Operative Treatmenten_US
dc.subjectDoxorubicinen_US
dc.subjectPoly(Vinyl Alcohol)en_US
dc.subjectPullulanen_US
dc.subjectCross-Linkingen_US
dc.subjectDeliveryen_US
dc.titleUsing embossing ice particulate method to prepare polyvinyl alcohol/ pullulan hydrogels with surface open pores loaded with microspheres for breast cancer treatment
dc.typeArticle

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