Impact of body weight-based dosing of palonosetron and ondansetron on postoperative nausea and vomiting following laparoscopic sleeve gastrectomy: a randomized, double-blind study

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dc.authoridVartanoglu Aktokmakyan, Talar/0000-0003-0583-6440|meric, serhat/0000-0001-7660-5688|demirgan, serdar/0000-0001-8129-5004|Karabay, Onder/0000-0002-3797-0102|Hacim, Nadir Adnan/0000-0002-3906-2538|SOLMAZ, ALI/0000-0002-3128-8639
dc.authorwosidçalışkan, ozan/JRW-0261-2023
dc.authorwosidVartanoglu Aktokmakyan, Talar/AFI-3036-2022
dc.authorwosidMeriç, Serhat/AAI-9670-2021
dc.authorwosidKarabay, Onder/L-5780-2018
dc.contributor.authorBurcu, Buesra
dc.contributor.authorHacim, Nadir Adnan
dc.contributor.authorCaliskan, Ozan
dc.contributor.authorDemirgan, Serdar
dc.contributor.authorAktokmakyan, Talar Vartanoglu
dc.contributor.authorMeric, Serhat
dc.contributor.authorDuymaz, Tomris
dc.date.accessioned2024-07-18T20:57:01Z
dc.date.available2024-07-18T20:57:01Z
dc.date.issued2024
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractBackground Postoperative nausea and vomiting (PONV) is a frequent adverse effect following laparoscopic sleeve gastrectomy. Palonosetron with a standard dosing (75 mu g) schedule has been questioned due to its low efficiency in obese patients. This study aimed to investigate the effectiveness and safety of the body weight-based dosing of palonosetron in managing PONV following laparoscopic sleeve gastrectomy. Methods A single-center, prospective, double-blinded randomized study was conducted between August 2021 and December 2021. Patients who underwent laparoscopic sleeve gastrectomy were prospectively recruited in the study. One hundred patients were randomly divided into palonosetron (Group P) and ondansetron (Group O). The demographic and clinical variables were recorded. The primary outcome of the study was the incidence of PONV between the two groups during the hospitalization. The secondary outcomes were the number of rescue anti-emetic and analgesic medications and the Functional Living Index-Emesis scores. Results There were 50 patients in each group (Group P and Group O). There were significant differences in the scores of POVN, nausea, and vomiting favoring Group P. In Group P, the rate of patients using rescue anti-emetics was significantly lower. The incidence of complete response and proportion of patients with higher Functional Living Index-Emesis scores were significantly higher in patients using palonosetron. Conclusions The use of palonosetron significantly reduced the incidence of PONV following laparoscopic sleeve gastrectomy. There was a significant improvement in the scores of Functional Living Index-Emesis in patients using palonosetron.en_US
dc.identifier.doi10.1080/00015458.2023.2184939
dc.identifier.endpage49en_US
dc.identifier.issn0001-5458
dc.identifier.issn2577-0160
dc.identifier.issue1en_US
dc.identifier.pmid36827206en_US
dc.identifier.scopus2-s2.0-85150601046en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1080/00015458.2023.2184939
dc.identifier.urihttps://hdl.handle.net/11411/8951
dc.identifier.volume124en_US
dc.identifier.wosWOS:000958303500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Chirurgica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPostoperative Nausea And Vomitingen_US
dc.subjectPalonosetronen_US
dc.subjectQuality Of Lifeen_US
dc.subjectDrug Side Effectsen_US
dc.subjectPreventionen_US
dc.subjectEfficacyen_US
dc.subjectRisken_US
dc.subjectDexamethasoneen_US
dc.subjectChemotherapyen_US
dc.subjectPredicten_US
dc.titleImpact of body weight-based dosing of palonosetron and ondansetron on postoperative nausea and vomiting following laparoscopic sleeve gastrectomy: a randomized, double-blind studyen_US
dc.typeArticleen_US

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