Is ursodeoxycholic acid crucial for ischemia/reperfusion-induced ovarian injury in rat ovary?

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dc.authoridsahin, cagdas/0000-0001-7346-3987|Erbas, Oytun/0000-0001-5427-8428|Yeniel, Ahmet Ozgur/0000-0002-5604-047X
dc.authorwosidakdemir, ali/ABB-4538-2020
dc.authorwosidsahin, cagdas/A-4180-2019
dc.authorwosidyeniel, ahmet özgür/E-8459-2011
dc.authorwosidERBAS, OYTUN/ABA-7380-2021
dc.contributor.authorAkdemir, Ali
dc.contributor.authorSahin, Cagdas
dc.contributor.authorErbas, Oytun
dc.contributor.authorYeniel, Ahmet O.
dc.contributor.authorSendag, Fatih
dc.date.accessioned2024-07-18T20:40:37Z
dc.date.available2024-07-18T20:40:37Z
dc.date.issued2015
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractUrsodeoxycholic acid is frequently used in cholestatic liver diseases. Also, it protects hepatocytes against oxidative stress induced by hydrophobic bile acids. We investigated the anti-oxidative effect of ursodeoxycholic acid on ischemia/reperfusion injury after ovarian de-torsion in rats. We designed five study groups. Group 1 (n = 6): Sham-operated group; group 2 (n = 6): torsion group; group 3 (n = 6): torsion and ursodeoxycholic acid, group 4 (n = 7): torsion/de-torsion group; and group 5 (n = 7): torsion/de-torsion and ursodeoxycholic acid. After that, ovarian samples were obtained and examined histologically and tissue levels of malondialdehyde were measured. Follicular degeneration, edema and inflammatory cells were significantly decreased in groups 3 and 5 in comparison with groups 2 and 4. Also, groups 4 and 5 were compared in terms of vascular congestion and hemorrhage and these were found to be significantly decreased in group 5. In addition, levels of malondialdehyde were significantly decreased in groups 3 and 5 in comparison with groups 2 and 4. We concluded that ursodeoxycholic acid might be useful to protect the ovary against ischemia and reperfusion injury.en_US
dc.identifier.doi10.1007/s00404-015-3646-9
dc.identifier.endpage450en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue2en_US
dc.identifier.pmid25663134en_US
dc.identifier.scopus2-s2.0-84930540562en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-015-3646-9
dc.identifier.urihttps://hdl.handle.net/11411/7136
dc.identifier.volume292en_US
dc.identifier.wosWOS:000355864000032en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvarian Torsionen_US
dc.subjectIschemia/Reperfusion İnjuryen_US
dc.subjectOxidative Stressen_US
dc.subjectUrsodeoxycholic Aciden_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectAdnexal Torsionen_US
dc.subjectDetorsionen_US
dc.subjectDamageen_US
dc.subjectExpressionen_US
dc.subjectCirrhosisen_US
dc.subjectOxytocinen_US
dc.subjectNeuronsen_US
dc.subjectDeathen_US
dc.titleIs ursodeoxycholic acid crucial for ischemia/reperfusion-induced ovarian injury in rat ovary?
dc.typeArticle

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