Expression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease

Basit Öğe Kaydı
dc.authoridbermek, hakan/0000-0003-2911-7678|CATAL, TUNC/0000-0003-2990-8680
dc.authorwosidbermek, hakan/S-7118-2018
dc.authorwosidCatal, Tunc/AAO-1200-2020
dc.authorwosidZeybek, Sakir Umit/AAD-2960-2020
dc.contributor.authorSezer Zhmurov, Cigdem
dc.contributor.authorTimirci-Kahraman, Ozlem
dc.contributor.authorAmadou, Fatimat'ul Zahara
dc.contributor.authorFazliogullari, Osman
dc.contributor.authorBasaran, Cem
dc.contributor.authorCatal, Tunc
dc.contributor.authorZeybek, Umit
dc.date.accessioned2024-07-18T20:45:35Z
dc.date.available2024-07-18T20:45:35Z
dc.date.issued2016
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractBackground: Neoangiogenesis inside the atherosclerotic plaques has been linked to progression of the disease. Egfl7, a key player in adult angiogenesis, was found to be upregulated in response to vascular injury in rats. Egfl7 encodes for miR-126-3p and miR-126-5p. Specific information about miRNA-126-5p and its expression in cardiovascular disease is scarce in comparison to that of miR-126-3p. Objectives: A gene expression study was conducted to investigate the levels of Egfl7 and miRNA126-5p in human carotid artery atherosclerotic plaques aiming to gain a better understanding of the role of neoangiogenesis within plaques and the mechanisms causing atherosclerosis progression. Methods:Egfl7 and miR-126-5p levels were studied in 14 plaque samples and 14 control samples using real-time PCR. The fold change between the carotid artery plaque tissue and control tissue was calculated using the 2(-CT) method. Results:Egfl7 was upregulated in the 11 plaque samples compared to controls, while expression levels of miR-126-5p was higher in eight of the plaque samples and lower in six as compared to control samples. Upregulation of miR-126-5p expression was correlated with high low-density lipoprotein (LDL) cholesterol (p=0.023). Conclusions: Our findings suggest that the upregulation of Egfl7 promotes neoangiogenesis within the plaques, contributing to disease progression.en_US
dc.description.sponsorshipIstanbul Technical University Scientific Research Projects Unit (ITU/BAP) [36999]en_US
dc.description.sponsorshipThis work was supported by the Istanbul Technical University Scientific Research Projects Unit (ITU/BAP) (Grant Number 36999). The authors thank Faruk Celik, Servet Tunoglu, and Ece Gizem Isikoren for all their help and support.en_US
dc.identifier.doi10.1089/gtmb.2015.0252
dc.identifier.endpage129en_US
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue3en_US
dc.identifier.pmid26799121en_US
dc.identifier.scopus2-s2.0-84960874047en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2015.0252
dc.identifier.urihttps://hdl.handle.net/11411/7619
dc.identifier.volume20en_US
dc.identifier.wosWOS:000371881900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofGenetic Testing and Molecular Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrornasen_US
dc.subjectAtherosclerosisen_US
dc.subjectMir-126en_US
dc.subjectAngiogenesisen_US
dc.titleExpression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease
dc.typeArticle

Dosyalar

Koleksiyon

Web of Science Indexed Publications
PubMed Indexed Publications
Scopus Indexed Publications