Mechanical support of pulmonary blood flow as a strategy to support the Norwood circulation-lumped parameter model study

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dc.authoridSinha, Pranava/0000-0002-5917-4668|Pekkan, Kerem/0000-0001-7637-4445|Ramakrishnan, Karthik Vaidyanathan/0000-0003-4042-4679|Peer, Syed/0000-0003-0859-2496
dc.authorwosidSinha, Pranava/ISS-5361-2023
dc.contributor.authorPeer, Syed Murfad
dc.contributor.authorYildirim, Canberk
dc.contributor.authorDesai, Manan
dc.contributor.authorRamakrishnan, Karthik
dc.contributor.authorSinha, Pranava
dc.contributor.authorJonas, Richard
dc.contributor.authorYerebakan, Can
dc.date.accessioned2024-07-18T20:45:41Z
dc.date.available2024-07-18T20:45:41Z
dc.date.issued2022
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractOBJECTIVES: We hypothesize that mechanical assistance of the pulmonary blood flow in a Norwood circulation can increase systemic blood flow and oxygen delivery. The aim of the study was to compare haemodynamics of an unassisted Norwood Blalock-Taussig shunt circulation with a mechanically assisted pulmonary flow-based Norwood circulation, using a lumped parameter computational model. METHODS: A neonatal circulatory lumped parameter model was developed to simulate a Norwood circulation with a 3.5-mm Blalock-Taussig shunt in a 3.5-kg neonate. A roller pump circulatory assist device with an inflow bladder was incorporated into the Norwood circulation to mechanically support the pulmonary circulation. Computer simulations were used to compare the haemodynamics of the assisted and unassisted circulations. Assisted and unassisted models with normal (56%) and reduced ejection fraction (30%) were compared. RESULTS: Compared to the unassisted Norwood circulation, the systemic flow in the assisted Norwood increased by 25% (ejection fraction = 56%) and 41% (ejection fraction = 30%). The central venous pressure decreased by up to 3 mmHg (both ejection fraction = 56% and ejection fraction = 30%) at a maximum pulmonary assist flow of 800 ml/min. Initiation of assisted pulmonary flow increased the arterial oxygen saturation by up to 15% and mixed venous saturation by up to 20%. CONCLUSIONS: This study demonstrates that an assisted pulmonary flow-based Norwood circulation has higher systemic flow and oxygen delivery compared to a standard Norwood Blalock-Taussig shunt circulation.en_US
dc.identifier.doi10.1093/ejcts/ezac262
dc.identifier.issn1010-7940
dc.identifier.issn1873-734X
dc.identifier.issue1en_US
dc.identifier.pmid35438164en_US
dc.identifier.scopus2-s2.0-85134360458en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1093/ejcts/ezac262
dc.identifier.urihttps://hdl.handle.net/11411/7626
dc.identifier.volume62en_US
dc.identifier.wosWOS:000790912700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofEuropean Journal of Cardio-Thoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSingle-Ventricle Physiologyen_US
dc.subjectNorwood Operationen_US
dc.subjectMechanical Circulatory Supporten_US
dc.subjectHemodynamic Statusen_US
dc.subjectShunten_US
dc.subjectHearten_US
dc.subjectInfantsen_US
dc.subjectDevicesen_US
dc.subjectVolumeen_US
dc.subjectRatioen_US
dc.titleMechanical support of pulmonary blood flow as a strategy to support the Norwood circulation-lumped parameter model studyen_US
dc.typeArticleen_US

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