Erythrocytic Reduced/Oxidized Glutathione and Serum Thiol/Disulfide Homeostasis in Patients with Opioid Use Disorder

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dc.WoS.categoriesPharmacology & PharmacyPsychiatryen_US
dc.authorid0000-0003-0917-2098en_US
dc.contributor.authorŞahin, Esra Kabadayı
dc.contributor.authorSenat, Almila
dc.contributor.authorSöğüt, İbrahim
dc.contributor.authorDuymaz, Tomris
dc.contributor.authorErel, Özcan
dc.date.accessioned2024-04-05T09:52:06Z
dc.date.available2024-04-05T09:52:06Z
dc.date.issued2023-12-03
dc.description.abstractBackground: This study aimed to evaluate oxidative damage by measuring erythrocytic reduced/oxidized glutathione as an intracellular thiol pool and serum thiol/disulfide homeostasis as an extracellular thiol pool in patients with opioid use disorder. Methods: In this prospective cross-sectional study, 33 male patients diagnosed with opioid use disorder and 30 healthy male controls were included. Sociodemographic characteristics and psychometric analyzes were performed and addiction characteristics (duration and amount of heroin use, usage methods) were recorded. For the evaluation of oxidative balance, intracellular reduced-oxidized glutathione (reduced glutathione and oxidized glutathione), and extracellular thiol-disulfide (native thiol and disulfide) levels were measured. Results: There was a decrease in reduced glutathione and native thiol levels and an increase in GSSG and SS levels. Similarly, while oxidized/reduced glutathione, oxidized/total glutathione%, and disulfide/native thiol % ratios increased, the ratio of reduced glutathione/total glutathione% and native thiol/total thiol% decreased. Moreover, a positive correlation was found between the level of both intracellular and extracellular oxidant molecules and the duration and amount of opioid use. Conclusion: Impaired intracellular reduced glutathione/oxidized glutathione and extracellular disulfide/native thiol homeostasis were found in patients with opioid use disorder. The intracellular and extracellular oxidative stress may cause complications related to chronic opioid use.en_US
dc.fullTextLevelFull Texten_US
dc.identifier.doi10.5152/pcp.2023.23636en_US
dc.identifier.issn2475-0581
dc.identifier.issn2475-0573
dc.identifier.scopus2-s2.0-85169784298en_US
dc.identifier.urihttps://hdl.handle.net/11411/5253
dc.identifier.urihttps://doi.org/10.5152/pcp.2023.23636
dc.identifier.wosWOS:001104857000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.issue3en_US
dc.language.isoenen_US
dc.nationalInternationalen_US
dc.numberofauthors5en_US
dc.pages170-176en_US
dc.publisherAVESen_US
dc.relation.ispartofPSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOXIDATIVE-STRESSen_US
dc.subjectHEROINen_US
dc.subjectMORPHINEIen_US
dc.subjectINVENTORYen_US
dc.subjectENZYMESen_US
dc.titleErythrocytic Reduced/Oxidized Glutathione and Serum Thiol/Disulfide Homeostasis in Patients with Opioid Use Disorderen_US
dc.typeArticleen_US
dc.volume33en_US

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