Diatom silica frustules-doped fibers for controlled release of melatonin for bone regeneration

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dc.authoridAtila, Deniz/0000-0001-9359-0131|Tezcaner, Aysen/0000-0003-4292-5856
dc.authorwosidAtila, Deniz/JEF-1986-2023
dc.contributor.authorDalgic, Ali Deniz
dc.contributor.authorAtila, Deniz
dc.contributor.authorTezcaner, Aysen
dc.contributor.authorGurses, Senih
dc.contributor.authorKeskin, Dilek
dc.date.accessioned2024-07-18T20:42:37Z
dc.date.available2024-07-18T20:42:37Z
dc.date.issued2023
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractSustained release of a bioactive agent from a tissue engineering scaffold is one of the most common strategies to improve regenerative potential of the construct. However, depending on the chemistry of the agent, achieving high enough loading and controlled release can be challenging depending on the scaffold materials. These shortcomings can be solved by novel scaffold design fabricated by appropriate techniques and materials for the target tissue. In this study, an electrospun scaffold was designed to improve osteogenic activity of cells and diatom silica frustules were used to sustain loading and controlled release of a hydrophilic molecule, melatonin. Fibrous scaffolds were produced via wet electrospinning of the polymer blend solution poly(hydroxybutyrate-co- hydroxyvalerate (PHBV)/poly(epsilon-caprolactone) (PCL) which contains melatonin loaded diatom frustules. In the 3D fiber matrix diatom frustules were covered with a polymer coat which successfully lowered melatonin release more than half through 7 days achieving a controlled release. Melatonin had a concentration dependent effect on ALP activity of cells, while scaffolds bearing melatonin loaded frustules have significantly improved ALP activity of Saos-2 cells. Developed scaffold system has successfully induced osteogenic activity by controlled melatonin delivery and silica nature of diatom frustules which hold potential use for bone tissue engineering.en_US
dc.identifier.doi10.1016/j.eurpolymj.2023.111858
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopus2-s2.0-85147195097en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2023.111858
dc.identifier.urihttps://hdl.handle.net/11411/7359
dc.identifier.volume186en_US
dc.identifier.wosWOS:000932498200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofEuropean Polymer Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiatom Frustuleen_US
dc.subjectSilicaen_US
dc.subjectMelatoninen_US
dc.subjectPhbven_US
dc.subjectPclen_US
dc.subjectBone Tissue Engineeringen_US
dc.subjectOsteoblastic Differentiationen_US
dc.subjectMicroparticlesen_US
dc.subjectDeliveryen_US
dc.subjectPolycaprolactoneen_US
dc.subjectMicrocapsulesen_US
dc.subjectTemperatureen_US
dc.subjectParticlesen_US
dc.subjectScaffoldsen_US
dc.titleDiatom silica frustules-doped fibers for controlled release of melatonin for bone regenerationen_US
dc.typeArticleen_US

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