Bifunctional sharkskin mimicked chitosan/graphene oxide membranes: Reduced biofilm formation and improved cytocompatibility

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dc.authoridÖzgür, Erdoğan/0000-0003-2494-4244|Ercan, Utku Kürşat/0000-0002-9762-2265|rostami, sabra/0000-0002-2687-1192|Puza, Fatih/0000-0002-9069-0847
dc.authorwosidGaripcan, Bora/AAS-9920-2020
dc.authorwosidErcan, Utku Kursat/AAX-1924-2020
dc.authorwosidGul, Ozgur/A-7841-2011
dc.authorwosidÖzgür, Erdoğan/G-5261-2012
dc.authorwosidErcan, Utku Kürşat/A-1658-2012
dc.authorwosidPuza, Fatih/AAA-5650-2021
dc.contributor.authorRostami, Sabra
dc.contributor.authorPuza, Fatih
dc.contributor.authorUcak, Meltem
dc.contributor.authorOzgur, Erdogan
dc.contributor.authorGul, Ozgur
dc.contributor.authorErcan, Utku Kursat
dc.contributor.authorGaripcan, Bora
dc.date.accessioned2024-07-18T20:42:29Z
dc.date.available2024-07-18T20:42:29Z
dc.date.issued2021
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractAntibacterial activity and cytocompatibility are the two essential characteristics that an ideal implantable biomaterial must possess simultaneously. Biomaterials with these characteristics can be fabricated via combination of chemical and topographical features. Herein, design and fabrication of a sharkskin mimicked Graphene Oxide modified Chitosan membrane with enhanced antibacterial and cytocompatibility properties was investigated. As a measure of antibacterial properties, viability of planktonic and bacterial biofilm was measured using gram-positive Staphylococcus aureus and gram-negative Escherichia coil. Results showed a significant reduction in bacterial adhesion and biofilm growth induced by sharkskin surface topography regardless of chemical modifications for both strains, hence proving the superior antibacterial activity of sharkskin topography. Furthermore, the highest level of cell viability and proliferation of cultured human keratinocyte (HaCaT) and mouse fibroblast (L929) cell lines belonged to Graphene Oxide (GO) coated sharkskin mimicked membranes. Our results indicate that GO coated (GOc) sharkskin mimicked membranes can significantly reduce bacterial biofilm formation in stationary culture conditions while promoting cytocompatibility. The duo of sharkskin surface topography and GO coating provides remarkable potentials as a cytocompatible and antibacterial biomaterial for diverse biomedical applications.en_US
dc.description.sponsorshipBogazici University Research Fund [6701]en_US
dc.description.sponsorshipThis study was partially supported by Bogazici University Research Fund (Grant No: 6701).en_US
dc.identifier.doi10.1016/j.apsusc.2020.148828
dc.identifier.issn0169-4332
dc.identifier.issn1873-5584
dc.identifier.scopus2-s2.0-85099004466en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.apsusc.2020.148828
dc.identifier.urihttps://hdl.handle.net/11411/7292
dc.identifier.volume544en_US
dc.identifier.wosWOS:000618304000004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofApplied Surface Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSharkskinen_US
dc.subjectGraphene Oxideen_US
dc.subjectChitosanen_US
dc.subjectBiomimetic Surfaceen_US
dc.subjectAntibacterialen_US
dc.subjectCytocompatibleen_US
dc.subjectGraphene Oxideen_US
dc.subjectAntibacterial Activityen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectDrag-Reductionen_US
dc.subjectChitosanen_US
dc.subjectSkinen_US
dc.subjectDesalinationen_US
dc.subjectOsteoblastsen_US
dc.subjectFabricationen_US
dc.subjectPropertyen_US
dc.titleBifunctional sharkskin mimicked chitosan/graphene oxide membranes: Reduced biofilm formation and improved cytocompatibilityen_US
dc.typeArticleen_US

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