Effects of Intermittent Fasting on Liver Steatosis and Fibrosis, Serum FGF-21 and Autophagy Markers in Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized Controlled Trial

Basit Öğe Kaydı
dc.authorid0000-0001-5655-8538
dc.authorid0000-0002-1878-9412
dc.authorid0000-0003-4518-5283
dc.authorid0000-0002-0139-676X
dc.contributor.authorKarahan, Tugce Ozlu
dc.contributor.authorAkyuz, Elvan Yilmaz
dc.contributor.authorKaradag, Demet Yilmaz
dc.contributor.authorYilmaz, Yusuf
dc.contributor.authorEren, Fatih
dc.date.accessioned2026-04-04T18:56:08Z
dc.date.available2026-04-04T18:56:08Z
dc.date.issued2025
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractBackground: This randomized controlled study sought to determine the effect of intermittent fasting on anthropometric measurements, fibroblast growth factor (FGF)-21, and autophagy markers, as well as on hepatic steatosis and fibrosis levels in overweight or obese patients with metabolic dysfunction-associated fatty liver disease (MAFLD). Methods: Patients were randomly assigned into two groups: received a dietary treatment involving 22-25 kcal/kg/day of energy for 8 weeks and followed the same dietary intervention and a 16:8 pattern. The extent of hepatic steatosis and fibrosis was determined using transient elastography on a FibroScan (R) device. The controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), determined by transient elastography, reflect hepatic steatosis and fibrosis, respectively. In duplicate, serum levels of FGF-21, Beclin-1, and ATG-5 were determined using enzyme-linked immunosorbent assay. Results: The study included 48 patients with a mean age of 48.2 +/- 1.4 years (27 female and 21 male). Improvements in anthropometric measurement and CAP and LSM levels and a decrease in serum FGF-21 levels were found in both groups (p < 0.05). Changes in the CAP and FGF-21 levels were higher in the energy + time-restricted diet group (p < 0.05). Autophagy-related protein (ATG)-5 levels increased only in the energy + time-restricted diet group [(0.74 (0.46-1.29) ng/mL vs. 0.95 (0.73-1.32) ng/mL, p = 0.03]. Conclusions: Intermittent fasting was potentially practical in the management of MAFLD. In particular, changes in FGF-21 and ATG-5 levels indicate the potential of intermittent fasting to regulate metabolic processes and autophagy. However, methodological limitations should be taken into consideration when interpreting the study results.
dc.description.sponsorshipScope of a doctoral thesis by Health Institutes of Turkiye (TUSEB) [24172]; Recep Tayyip Erdogan University Development Foundation [02025002003275]
dc.description.sponsorshipThis study was supported within the scope of a doctoral thesis by Health Institutes of Turkiye (TUSEB) with a grant number of 24172. The APC was funded by Recep Tayyip Erdogan University Development Foundation (Grant Number: 02025002003275).
dc.identifier.doi10.3390/life15050696
dc.identifier.doi10.3390/life15050696
dc.identifier.issn2075-1729
dc.identifier.issue5
dc.identifier.pmid40430125
dc.identifier.scopus2-s2.0-105006576466
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/life15050696
dc.identifier.urihttps://hdl.handle.net/11411/10704
dc.identifier.volume15
dc.identifier.wosWOS:001497521400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofLife-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectIntermittent Fasting
dc.subjectFibroblast Growth Factor 21
dc.subjectAutophagy
dc.subjectFatty Liver
dc.subjectTime-Restricted Eating
dc.titleEffects of Intermittent Fasting on Liver Steatosis and Fibrosis, Serum FGF-21 and Autophagy Markers in Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized Controlled Trial
dc.typeArticle

Dosyalar

Koleksiyon

Web of Science Indexed Publications
PubMed Indexed Publications
Scopus Indexed Publications