Breast Cancer Plasticity after Chemotherapy Highlights the Need for Re-Evaluation of Subtyping in Residual Cancer and Metastatic Tissues

Basit Öğe Kaydı
dc.authorid0000-0002-5475-281X
dc.authorid0000-0003-2623-4860
dc.authorid0000-0003-4768-7551
dc.authorid0000-0001-5597-0125
dc.authorid0000-0001-5275-7441
dc.authorid0000-0002-2966-4455
dc.authorid0000-0003-0200-7962
dc.contributor.authorPadzinska-Pruszynska, Irena Barbara
dc.contributor.authorAkbar, Muhammad Waqas
dc.contributor.authorIsbilen, Murat
dc.contributor.authorGorka, Emilia
dc.contributor.authorKucukkaraduman, Baris
dc.contributor.authorCanli, Secil Demirkol
dc.contributor.authorTaciak, Bartlomiej
dc.date.accessioned2026-04-04T18:56:07Z
dc.date.available2026-04-04T18:56:07Z
dc.date.issued2024
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractThis research paper presents a novel approach to identifying biomarkers that can be used to prognosticate patients with triple-negative breast cancer (TNBC) eligible for neoadjuvant therapy. The study utilized survival and RNA sequencing data from a cohort of TNBC patients and identified 276 genes whose expression was related to survival in such patients. The gene expression data were then used to classify patients into two major groups based on the presence or absence of Wingless/Integrated-pathway (Wnt-pathway) and mesenchymal (Mes) markers (Wnt/Mes). Patients with a low expression of Wnt/Mes-related genes had a favorable outcome, with no deaths observed during follow-up, while patients with a high expression of Wnt/Mes genes had a higher mortality rate of 50% within 19 months. The identified gene list could be validated and potentially used to shape treatment options for TNBC patients eligible for neoadjuvant therapy providing valuable insights into the development of more effective treatments for TNBC. Our data also showed significant variation in gene expression profiles before and after chemotherapy, with most tumors switching to a more mesenchymal/stem cell-like profile. To verify this observation, we performed an in silico analysis to classify breast cancer tumors in Prediction Analysis of Microarray 50 (PAM50) molecular classes before treatment and after treatment using gene expression data. Our findings demonstrate that following drug intervention and metastasis, certain tumors undergo a transition to alternative subtypes, resulting in diminished therapeutic efficacy. This underscores the necessity for reevaluation of patients who have experienced relapse or metastasis post-chemotherapy, with a focus on molecular subtyping. Tailoring treatment strategies based on these refined subtypes is imperative to optimize therapeutic outcomes for affected individuals.
dc.description.sponsorshipNational Centre for Research and Development (Narodowe Centrum Badanacute; i Rozwoju NCBiR)
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.3390/ijms25116054
dc.identifier.doi10.3390/ijms25116054
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue11
dc.identifier.pmid38892243
dc.identifier.scopus2-s2.0-85195909822
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms25116054
dc.identifier.urihttps://hdl.handle.net/11411/10701
dc.identifier.volume25
dc.identifier.wosWOS:001245594400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectTnbc
dc.subjectBreast Cancer
dc.subjectPrognostic Markers
dc.subjectPam50 Plasticity
dc.subjectWnt/Mes
dc.titleBreast Cancer Plasticity after Chemotherapy Highlights the Need for Re-Evaluation of Subtyping in Residual Cancer and Metastatic Tissues
dc.typeArticle

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