Evaluation of Resting Cardiac Power Output as a Prognostic Factor in Patients with Advanced Heart Failure

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dc.authoridYildiz, Omer/0000-0002-3632-3405|aslan, gamze/0000-0003-4000-3292
dc.authorwosidYildiz, Omer/AAK-6464-2020
dc.authorwosidaslan, gamze/O-9004-2014
dc.contributor.authorYildiz, Omer
dc.contributor.authorAsian, Gamze
dc.contributor.authorDemirozu, Zumrut T.
dc.contributor.authorYenigun, Cemal Deniz
dc.contributor.authorYazicioglu, Nuran
dc.date.accessioned2024-07-18T20:42:29Z
dc.date.available2024-07-18T20:42:29Z
dc.date.issued2017
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractIf the heart is represented by a hydraulic pump, cardiac power represents the hydraulic function of the heart. Cardiac pump function is frequently determined through left ventricular ejection fraction using imaging. This study aims to validate resting cardiac power output (CPO) as a predictive biomarker in patients with advanced heart failure (HF). One hundred and seventy-two patients with HF severe enough to warrant cardiac transplantation were retrospectively reviewed at a single tertiary care institution between September 2010 and July 2013. Patients were initially evaluated with simultaneous right-sided and left sided cardiac catheter-based hemodynamic measurements, followed by longitudinal follow-up (median of 52 months) for adverse events (cardiac mortality, cardiac transplantation, or ventricular assist device placement). Median resting CPO was 0.54 W (long rank chi-square = 33.6; p < 0.0001). Decreased resting CPO (<0.54 W) predicted increased risk for adverse outcomes. Fifty cardiac deaths, 10 cardiac transplants, and 12 ventricular assist device placements were documented. The prognostic relevance of resting CPO remained significant after adjustment for age, gender, left ventricular ejection fraction, mean arterial pressure, pulmonary vascular resistance, right atrial pressure, and estimated glomerular filtration rate (HR, 3.53; 95% confidence interval, 1.66 to 6.77; p = 0.0007). In conclusion, lower resting CPO supplies independent prediction of adverse outcomes. Thus, it could be effectively used for risk stratification in patients with advanced HF. (C) 2017 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.amjcard.2017.06.028
dc.identifier.endpage979en_US
dc.identifier.issn0002-9149
dc.identifier.issn1879-1913
dc.identifier.issue6en_US
dc.identifier.pmid28739034en_US
dc.identifier.scopus2-s2.0-85025136740en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage973en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjcard.2017.06.028
dc.identifier.urihttps://hdl.handle.net/11411/7287
dc.identifier.volume120en_US
dc.identifier.wosWOS:000411852700014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Inc-Elsevier Science Incen_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExercise Oxygen-Consumptionen_US
dc.subjectAmbulatory Patientsen_US
dc.subjectMortalityen_US
dc.subjectTransplantationen_US
dc.subjectDysfunctionen_US
dc.subjectDiseaseen_US
dc.titleEvaluation of Resting Cardiac Power Output as a Prognostic Factor in Patients with Advanced Heart Failureen_US
dc.typeArticleen_US

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