Optimizing percutaneous pulmonary valve implantation with patient-specific 3D-printed pulmonary artery models and hemodynamic assessment

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dc.authorscopusid55907957400
dc.authorscopusid57201658583
dc.authorscopusid58820693500
dc.authorscopusid6602223025
dc.authorscopusid6602639256
dc.contributor.authorOdemis, E.
dc.contributor.authorAKA, İ.B.
dc.contributor.authorAli, M.H.A.
dc.contributor.authorGumus, T.
dc.contributor.authorPekkan, K.
dc.date.accessioned2024-07-18T20:17:25Z
dc.date.available2024-07-18T20:17:25Z
dc.date.issued2023
dc.description.abstractBackground: Percutaneous pulmonary valve implantation (PPVI) has emerged as a less invasive alternative for treating severe pulmonary regurgitation after tetralogy of Fallot (TOF) repair in patients with a native right ventricular outflow tract (RVOT). However, the success of PPVI depends on precise patient-specific valve sizing, the avoidance of oversizing complications, and optimal valve performance. In recent years, innovative adaptations of commercially available cardiovascular mock loops have been used to test conduits in the pulmonary position. These models are instrumental in facilitating accurate pulmonic valve sizing, mitigating the risk of oversizing, and providing insight into the valve performance before implantation. This study explored the utilization of custom-modified mock loops to implant patient-specific 3D-printed pulmonary artery geometries, thereby advancing PPVI planning and execution. Material and Methods: Patient-specific 3D-printed pulmonary artery geometries of five patients who underwent PPVI using Pulsta transcatheter heart valve (THV) ® were tested in a modified ViVitro pulse duplicator system®. Various valve sizes were subjected to 10 cycles of testing at different cardiac output levels. The transpulmonary systolic and regurgitation fractions of the valves were also recorded and compared. Results: A total of 39 experiments were conducted using five different patient geometries and several different valve sizes (26, 28, 30, and 32?mm) at 3, 4, and 5?L/min cardiac output at heart rates of 70 beats per minute (bpm) and 60/40 systolic/diastolic ratios. The pressure gradients and regurgitation fractions of the tested valve sizes in the models were found to be similar to the pressure gradients and regurgitation fractions of valves used in real procedures. However, in two patients, different valve sizes showed better hemodynamic values than the actual implanted valves. Discussion: The use of 3D printing technology, electromagnetic flow meters, and the custom-modified ViVitro pulse duplicator system® in conjunction with patient-specific pulmonary artery models has enabled a comprehensive assessment of percutaneous pulmonic valve implantation performance. This approach allows for accurate valve sizing, minimization of oversizing risks, and valuable insights into hemodynamic behavior before implantation. The data obtained from this experimental setup will contribute to advancing PPVI procedures and offer potential benefits in improving patient outcomes and safety. 2024 Odemis, AKA, Ali, Gumus and Pekkan.en_US
dc.description.sponsorship2023 B01 33653en_US
dc.description.sponsorshipThis project was partially funded by TUSEB (Project number: 2023 B01 33653). Acknowledgmentsen_US
dc.identifier.doi10.3389/fcvm.2023.1331206
dc.identifier.issn2297-055X
dc.identifier.scopus2-s2.0-85182627599en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fcvm.2023.1331206
dc.identifier.urihttps://hdl.handle.net/11411/6537
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofFrontiers in Cardiovascular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject3d Modelsen_US
dc.subjectHemodynamicen_US
dc.subjectİn Vitro Hemodynamicen_US
dc.subjectPercutaneous Pulmonary Valve İmplantationen_US
dc.subjectPulstaen_US
dc.subjectTetralogy Of Falloten_US
dc.subjectVivitroen_US
dc.subjectVivitro Percutaneous Pulmonary Valve İmplantationen_US
dc.subjectArticleen_US
dc.subjectComputed Tomographic Angiographyen_US
dc.subjectDiastolic Blood Pressureen_US
dc.subjectEchocardiographyen_US
dc.subjectElectrocardiographyen_US
dc.subjectFallot Tetralogyen_US
dc.subjectFemaleen_US
dc.subjectGeometryen_US
dc.subjectHeart Outputen_US
dc.subjectHeart Rateen_US
dc.subjectHeart Right Ventricle Outflow Tracten_US
dc.subjectHemodynamicsen_US
dc.subjectHumanen_US
dc.subjectHuman Experimenten_US
dc.subjectMaleen_US
dc.subjectMean Arterial Pressureen_US
dc.subjectNuclear Magnetic Resonance İmagingen_US
dc.subjectOptical Coherence Tomography Angiographyen_US
dc.subjectPercutaneous Pulmonary Valve İmplantationen_US
dc.subjectPressure Gradienten_US
dc.subjectPulmonary Arteryen_US
dc.subjectPulmonary Valveen_US
dc.subjectSurgical Techniqueen_US
dc.subjectSystolic Blood Pressureen_US
dc.subjectThree Dimensional Printingen_US
dc.subjectTreatment Outcomeen_US
dc.titleOptimizing percutaneous pulmonary valve implantation with patient-specific 3D-printed pulmonary artery models and hemodynamic assessmenten_US
dc.typeArticleen_US

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