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    Effects of prenatal exposure to extremely low frequency magnetic field on testicular tissues of male rats
    (2019) Erdem, Erkan; Sarıbal, Devrim
    Aim: Extremely low-frequency magnetic field (ELF-MF) is produced by a large variety of electronic devices in everyday use. This study was therefore undertaken to examine the effects of ELF-MF on oxidative stress parameters in rat testicular tissue.Material and Methods: Twenty-five Sprague Dawley rats were exposed to 50 Hz 500?T ELF-MF 24 hours a day, starting from the prenatal period. The exposure continued for further 60 days following the birth. Testicular tissue samples were collected and analyzed. The levels of an oxidative stress marker MDA, and an antioxidant scavenger GSH were investigated.Results: Long-term exposure to ELF-MF increased MDA levels and decreased GSH levels significantly. No correlation was shown between MDA and GSH levels.Conclusion: According to the results of this study, ELF-MF exposure could impair oxidant-antioxidant function and might increase oxidative stress and lipid peroxidation in the testicular tissue.
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    Effects of prenatal exposure to extremely low frequency magnetic field on testicular tissues of male rats
    (Annals of Medical Research, 2019) Sarıbal, Devrim; Erdem, Erkan
    ABSTRACT: Aim: Extremely low-frequency magnetic field (ELF-MF) is produced by a large variety of electronic devices in everyday use. This study was therefore undertaken to examine the effects of ELF-MF on oxidative stress parameters in rat testicular tissue. Material and Methods: Twenty-five Sprague Dawley rats were exposed to 50 Hz 500?T ELF-MF 24 hours a day, starting from the prenatal period. The exposure continued for further 60 days following the birth. Testicular tissue samples were collected and analyzed. The levels of an oxidative stress marker MDA, and an antioxidant scavenger GSH were investigated. Results: Long-term exposure to ELF-MF increased MDA levels and decreased GSH levels significantly. No correlation was shown between MDA and GSH levels. Conclusion: According to the results of this study, ELF-MF exposure could impair oxidant-antioxidant function and might increase oxidative stress and lipid peroxidation in the testicular tissue.
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    Metformin decreases testicular damages following ischaemia/reperfusion injury in rats
    (Wiley, 2020) Saribal, Devrim; Erdem, Erkan; Gungor-Ordueri, Nazli Ece; Usta, Akin; Karakus, Cemil; Karacan, Meric
    The effects of metformin on a testicular torsion injury in adolescent rat testis after I/R were evaluated in the present study. Forty adolescent rats were divided into five groups with eight rats per group: a control group; a sham-operated group; an ischaemia group, where torsion was applied for 4 hr and testis was examined immediately after detorsion; an I/R group, where torsion was applied for 4 hr and the testis was examined 4 hr after detorsion; and an I/R + M group, where the metformin (300 mg/kg) administration was added to the identical procedures used for the I/R group. Spermatogenesis, basal membrane integrity and cleaved caspase-3 expression were assessed. The I/R + M group had a significantly higher Johnsen score than the I/R group (7.9 +/- 0.1 vs. 7.5 +/- 0.2; p F-value = 14.2). Failure of basal membrane integrity was highest in the ischaemia group (45 +/- 5) compared to the other groups (control group, 20 +/- 5; sham-operated group, 16.6 +/- 2.8), but not different between the I/R + M (31.6 +/- 12.5) and the I/R groups (25 +/- 3.5). Cleaved caspase-3 expression was highest in the ischaemia group (73.5 +/- 0.7), and significantly lower in the I/R + M group (33.4 +/- 0.9) than the I/R group (58.5 +/- 0.2; p F-value = 7.6). Metformin decreases testicular damage by exerting protection against the harmful effects of I/R on spermatogenesis and alleviating apoptosis in adolescent rat testis.