The effect of multifocal and multicentric tumours on local recurrence and survival outcomes in breast cancer

dc.authoridOzmen, Vahit/0000-0003-2973-8247|Celebi, Filiz/0000-0003-4020-4019;
dc.authorwosidOzturk, Alper/U-4718-2017
dc.authorwosidIlgun, Serkan/GNW-4901-2022
dc.authorwosidOzmen, Vahit/AAE-3904-2020
dc.authorwosidCelebi, Filiz/AAR-3071-2020
dc.authorwosidErdogan Iyigun, zeynep/KIK-2972-2024
dc.contributor.authorOzturk, Alper
dc.contributor.authorIlgun, Serkan
dc.contributor.authorUcuncu, Muhammed
dc.contributor.authorGachayev, Firuz
dc.contributor.authorOrdu, Cetin
dc.contributor.authorAlco, Gul
dc.contributor.authorElbuken, Filiz
dc.date.accessioned2024-07-18T20:57:54Z
dc.date.available2024-07-18T20:57:54Z
dc.date.issued2021
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractPurpose: The purpose of this study was to compare the multifocal (MF)/multicentric (MC) breast cancers with unifocal (UF) breast cancers in terms of tumour characteristics, treatment methods, loco-regional recurrence and survival rates. Methods: Patients who were treated with a diagnosis of early-stage breast cancer (stage I,II) and had regular follow-up were included in the study. MF tumours were defined as having more than one tumour focus in the same quadrant, whereas MC tumours refered to the presence of more than one tumour focus in different quadrants. Results: In total, 1865 patients with invasive breast cancer were evaluated, 1493 (80.1%) of whom had UF cancer, 330 (17.7%) had MF cancer, and 42 (2.3%) had MC cancer. After comparing the groups with each other, it was seen that MF and MC breast cancers occurred more often at early ages and that lymph node invasion (LNI) was greater. No differences were seen between the 3 groups in terms of local recurrence-free survival (RFS) and overall survival (OS) rates. In multivariate analysis, it was found that MF and MC tumours had no impact on local recurrence and OS. In multivariate analysis, it was understood that HER2 positivity and triple-negative breast cancer (TNBC) had an impact on local recurrence, and age, lymphovascular invasion (LVI), T3 tumour, lymph node positivity and TNBC subtype had an impact on OS. Conclusion: Although MC and MF tumours show aggressive features such as high lymph node positivity and LVI, they have similar loco-regional recurrence and survival rates to UF tumours.en_US
dc.identifier.endpage203en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue1en_US
dc.identifier.pmid33721452en_US
dc.identifier.scopus2-s2.0-85102914183en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage196en_US
dc.identifier.urihttps://hdl.handle.net/11411/8974
dc.identifier.volume26en_US
dc.identifier.wosWOS:000642340700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultifocal Breast Canceren_US
dc.subjectMulticentric Breast Canceren_US
dc.subjectLocal Recurrenceen_US
dc.subjectSurvivalen_US
dc.subjectConservative Surgeryen_US
dc.subjectTherapyen_US
dc.subjectImpacten_US
dc.subjectCarcinomaen_US
dc.titleThe effect of multifocal and multicentric tumours on local recurrence and survival outcomes in breast canceren_US
dc.typeArticleen_US

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