Finite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations

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dc.authorid0000-0003-1066-3791
dc.authorid0000-0001-6707-2728
dc.authorid0000-0001-8134-9068
dc.authorid0000-0003-3825-9934
dc.authorid0000-0002-9491-4115
dc.authorid0000-0001-9885-6648
dc.contributor.authorMutlu, Onur
dc.contributor.authorMazhar, Noaman
dc.contributor.authorSaribay, Murat
dc.contributor.authorYavuz, Mehmet Metin
dc.contributor.authorOzturk, Deniz
dc.contributor.authorGhareeb, Abdel Naser
dc.contributor.authorYalcin, Huseyin Cagatay
dc.date.accessioned2026-04-04T18:56:08Z
dc.date.available2026-04-04T18:56:08Z
dc.date.issued2025
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractBackground/Objectives: For transcatheter aortic valve implantation (TAVI) therapy, a catheter-guided crimped valve is deployed into the aortic root. Valve types such as Edwards balloon-expandable valves and Medtronic self-expandable valves come in different sizes and are chosen based on patient-specific aortic anatomy, including aortic root diameter measurement. Complications may arise due to variations in anatomical characteristics and the implantation procedure, making pre-implantation assessment important for predicting complications. Methods: Computational modeling, particularly finite element analysis (FEA), has become popular for assessing wall stresses and deformations in TAVI. In this study, a finite element model including the aorta, native leaflets, and TAVI device was used to simulate procedures and assess patient-specific wall stresses and deformations. Results: Using the Medtronic Evolut R valve, we simulated TAVI for 14 patients to analyze the effects of geometrical variations on structural stresses. Virtual TAVIs with different valve sizes were also simulated to study the influence of TAV size on stresses. Our results show that variations in aortic wall geometries and TAV sizes significantly influence wall stresses and deformations. Conclusions: Our study is one of the first comprehensive FEA investigations of aortic geometrical variations and valve sizes on post-TAVI stresses, demonstrating the non-linear relationship between aortic dimensions, TAV sizes, and wall stresses.
dc.description.sponsorshipQatar National Research Fund (QNRF), National Priority Research Program; Qatar National Library; [NPRP13S-0108-200024]
dc.description.sponsorshipThis work was funded by the Qatar National Research Fund (QNRF), National Priority Research Program (Grant number NPRP13S-0108-200024). Open-access funding was provided by the Qatar National Library.
dc.identifier.doi10.3390/jcm14030850
dc.identifier.doi10.3390/jcm14030850
dc.identifier.issn2077-0383
dc.identifier.issue3
dc.identifier.pmid39941521
dc.identifier.scopus2-s2.0-85217628378
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm14030850
dc.identifier.urihttps://hdl.handle.net/11411/10703
dc.identifier.volume14
dc.identifier.wosWOS:001418733000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectTranscatheter Aortic Valve Implantation
dc.subjectFinite Element Analysis
dc.subjectAortic Stenosis
dc.subjectEvolut-R
dc.subjectContact Pressure
dc.subjectVon Mises Stresses
dc.subjectAbaqus
dc.titleFinite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations
dc.typeArticle

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