RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells

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dc.authoridKozanoglu, Ilknur/0000-0002-5268-1210|ÖZTOP, SIDIKA/0000-0001-5653-6080|AKA, YELİZ/0000-0002-1708-4779|karakas, bahriye/0000-0001-9616-4656|KUTUK, OZGUR/0000-0001-9854-7220|Temel, Sehime G/0000-0002-9802-0880
dc.authorwosidKozanoglu, Ilknur/AAE-1241-2021
dc.authorwosidTemel, Sehime/AAG-8385-2021
dc.authorwosidGul, Ozgur/A-7841-2011
dc.authorwosidÖZTOP, SIDIKA/AAJ-7911-2020
dc.authorwosidÇelik, Hüsnü/AAL-1923-2021
dc.authorwosidAKA, YELİZ/JXM-3830-2024
dc.authorwosidkarakas, bahriye/GOK-0965-2022
dc.contributor.authorTemel, Sehime Gulsun
dc.contributor.authorGiray, Asli
dc.contributor.authorKarakas, Bahriye
dc.contributor.authorGul, Ozgur
dc.contributor.authorKozanoglu, Ilknur
dc.contributor.authorCelik, Husnu
dc.contributor.authorBasaga, Huveyda
dc.date.accessioned2024-07-18T20:40:38Z
dc.date.available2024-07-18T20:40:38Z
dc.date.issued2020
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractOvarian cancer remains one of the most frequent causes of cancer-related death in women. Many patients with ovarian cancer suffer from de novo or acquired resistance to chemotherapy. Here, we report that RAB25 suppresses chemotherapy-induced mitochondrial apoptosis signaling in ovarian cancer cell lines and primary ovarian cancer cells. RAB25 blocks chemotherapy-induced apoptosis upstream of mitochondrial outer membrane permeabilization by either increasing antiapoptotic BCL-2 proteins or decreasing proapoptotic BCL-2 proteins. In particular, BAX expression negatively correlates with RAB25 expression in ovarian cancer cells. BH3 profiling assays corroborated that RAB25 decreases mitochondrial cell death priming. Suppressing RAB25 by means of RNAi or RFP14 inhibitory hydrocarbon-stapled peptide sensitizes ovarian cancer cells to chemotherapy as well as RAB25-mediated proliferation, invasion and migration. Our data suggest that RAB25 is a potential therapeutic target for ovarian cancer.en_US
dc.description.sponsorshipTUBITAK [113S871]; Baskent University Research Funds; Science Academy BAGEP programen_US
dc.description.sponsorshipThis study was supported by TUBITAK 113S871 and Baskent University Research Funds. Ozgur Kutuk acknowledges support from the Science Academy BAGEP program.en_US
dc.identifier.doi10.1007/s10495-020-01635-z
dc.identifier.endpage816en_US
dc.identifier.issn1360-8185
dc.identifier.issn1573-675X
dc.identifier.issue11.Araen_US
dc.identifier.pmid32901335en_US
dc.identifier.scopus2-s2.0-85090440803en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage799en_US
dc.identifier.urihttps://doi.org/10.1007/s10495-020-01635-z
dc.identifier.urihttps://hdl.handle.net/11411/7155
dc.identifier.volume25en_US
dc.identifier.wosWOS:000567421400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofApoptosisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRab25en_US
dc.subjectChemotherapyen_US
dc.subjectBcl-2 Proteinsen_US
dc.subjectOvarian Canceren_US
dc.subjectBcl-2en_US
dc.subjectExpressionen_US
dc.subjectMetastasisen_US
dc.subjectInhibitionen_US
dc.subjectInvasionen_US
dc.subjectOverexpressionen_US
dc.subjectProliferationen_US
dc.subjectContributesen_US
dc.subjectBiomarkersen_US
dc.subjectKidneyen_US
dc.titleRAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cellsen_US
dc.typeArticleen_US

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