The effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes in patients with breast cancer

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dc.authoridÜnal, Çağlar/0000-0003-3245-1570|Ozmen, Vahit/0000-0003-2973-8247|kapucuoglu, Fatma Nilgün/0000-0002-0016-6479|Celebi, Filiz/0000-0003-4020-4019|ALCO, GUL/0000-0002-3592-9923|Erdogan Iyigun, zeynep/0000-0001-5353-1452|Ozturk, Alper/0000-0002-7137-5374|aktepe, fatma/0000-0002-3491-0665|Ordu, Cetin/0000-0003-4423-8005
dc.authorwosidOzturk, Alper/U-4718-2017
dc.authorwosidÜnal, Çağlar/ITT-4695-2023
dc.authorwosidOzmen, Vahit/AAE-3904-2020
dc.authorwosidkapucuoglu, Fatma Nilgün/ABH-4659-2022
dc.authorwosidCelebi, Filiz/AAR-3071-2020
dc.authorwosidALCO, GUL/B-7990-2016
dc.contributor.authorIlgun, Ahmet Serkan
dc.contributor.authorAktepe, Fatma
dc.contributor.authorGonullu, Onur
dc.contributor.authorKapucuoglu, Nilgun
dc.contributor.authorYararbas, Kanay
dc.contributor.authorAlco, Gul
dc.contributor.authorOzturk, Alper
dc.date.accessioned2024-07-18T20:49:11Z
dc.date.available2024-07-18T20:49:11Z
dc.date.issued2022
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractAim: This study investigated the effect of neoadjuvant chemotherapy (NAC) on stromal tumor-infiltrating lymphocytes (sTILs) and their treatment response. Materials & methods: One hundred fifteen patients with pre-NAC core biopsies and post-NAC surgical resection specimens were reviewed. Results: There was no significant change between pre- and post-treatment sTILs. Both pre- and post-NAC sTILs were significantly lower in patients with luminal A subtype. An increase in sTILs was observed in 21 (25.9%) patients after NAC, a decrease in 29 (35.8%) and no change in 31 (38.3%; p = 0.07). Pretreatment sTIL density was independent predictor of pathological complete response in multivariate analyses (odds ratio: 1.025, 95% CI: 1.003-1.047; p = 0.023). Conclusion: High sTIL density in core biopsies was independently related to pathological complete response. In addition, ER appears to be the most crucial factor determining the rate of sTIL. Plain language summary New studies have shown that the tumor microenvironment is critical in tumor behavior. Immune cells surrounding tumor cells are the main components of the tumor microenvironment. Our study aimed to investigate the change in immune cells before and after chemotherapy in breast cancer patients. Our study included 115 patients. All patients underwent chemotherapy before surgery to shrink the tumor. Tru-cut biopsy pieces and the breast tissue obtained after surgery were examined. The presence of estrogen or progesterone receptors on tumor cells decreased the number of immune cells surrounding the tumor cells. The number of immune cells did not decrease after chemotherapy. Another finding was that the greater the number of immune cells around the tumor, the more likely that the tumor would disappear after chemotherapy.en_US
dc.identifier.doi10.2217/fon-2022-0157
dc.identifier.endpage3298en_US
dc.identifier.issn1479-6694
dc.identifier.issn1744-8301
dc.identifier.issue29en_US
dc.identifier.pmid36017739en_US
dc.identifier.scopus2-s2.0-85140274865en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3289en_US
dc.identifier.urihttps://doi.org/10.2217/fon-2022-0157
dc.identifier.urihttps://hdl.handle.net/11411/8122
dc.identifier.volume18en_US
dc.identifier.wosWOS:000844562800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltden_US
dc.relation.ispartofFuture Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectİmmune Markersen_US
dc.subjectİmmunogenicityen_US
dc.subjectLymphocytic İnfiltrateen_US
dc.subjectİmmune-Cell İnfiltrationen_US
dc.subjectNeoadjuvant Treatmenten_US
dc.subjectPathologic Complete Responseen_US
dc.subjectStılen_US
dc.subjectStıl Changeen_US
dc.subjectTumor İnfiltrating Lymphocyteen_US
dc.subjectTumor Microenvironmenten_US
dc.subjectMacrophage Activationen_US
dc.subjectEstrogenen_US
dc.subjectProgesteroneen_US
dc.titleThe effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes in patients with breast cancer
dc.typeArticle

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