Investigation of the effect of ghrelin on bone fracture healing in rats

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dc.authoridGeneci, Ferhat/0000-0002-5039-4664|ocak, mert/0000-0001-6832-6208|Dalgıç, Ali Deniz/0000-0003-2904-1204|Ceritoglu, Kubilay Ugurcan/0000-0002-7111-6831
dc.authorwosidGeneci, Ferhat/AAM-1425-2021
dc.authorwosidocak, mert/G-9404-2017
dc.authorwosidÇaydere, Muzaffer/HKV-5427-2023
dc.authorwosidDalgıç, Ali Deniz/AAZ-8985-2020
dc.authorwosidSenes, Mehmet/AAG-6802-2019
dc.contributor.authorErener, Tamer
dc.contributor.authorCeritoglu, Kubilay Ugurcan
dc.contributor.authorAktekin, Cem Nuri
dc.contributor.authorDalgic, Ali Deniz
dc.contributor.authorKeskin, Dilek
dc.contributor.authorGeneci, Ferhat
dc.contributor.authorOcak, Mert
dc.date.accessioned2024-07-18T20:47:28Z
dc.date.available2024-07-18T20:47:28Z
dc.date.issued2021
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractGhrelin is known to have effects on proliferation and differentiation of osteoblasts and improvement of bone mineral density in rats. However, no experimental research on ghrelin's effects on fracture healing has been reported. In this context, the effect of ghrelin on the union of femoral shaft fractures was examined in this study by evaluating whether ghrelin will directly contribute to fracture healing. Forty male Wistar-Albino rats were divided into two groups as control and experimental (ghrelin treated) and standard closed shaft fractures were created in the left femurs of all rats. Daily ghrelin injections were applied to the experimental groups and equal numbers of rats were killed after 14 and 28 days following fracture formation. Tissue samples were examined with radiological, biomechanical, biochemical and histological analyses. Densitometry study showed that bone mineral density was improved after 28 days of ghrelin treatment compared to control. On histological examination, at the end of the 14 and 28 days of recovery, significant union was observed in the ghrelin-treated group. The ghrelin-treated group had higher breaking strength and stiffness at the end of 28 days of recovery. Biochemically, ALP levels were found to be higher in the ghrelin-treated group at the end of 28 days of recovery. Results showed that ghrelin directly contributes to fracture healing and it is promising to consider the effect of ghrelin on fracture healing in human studies with pharmacological applications.en_US
dc.identifier.doi10.1111/1440-1681.13544
dc.identifier.endpage1390en_US
dc.identifier.issn0305-1870
dc.identifier.issn1440-1681
dc.identifier.issue10en_US
dc.identifier.pmid34152642en_US
dc.identifier.scopus2-s2.0-85109103610en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1382en_US
dc.identifier.urihttps://doi.org/10.1111/1440-1681.13544
dc.identifier.urihttps://hdl.handle.net/11411/7805
dc.identifier.volume48en_US
dc.identifier.wosWOS:000669714900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Remodellingen_US
dc.subjectFracture Healingen_US
dc.subjectFracture Repairen_US
dc.subjectGhrelinen_US
dc.subjectGrowth-Hormoneen_US
dc.subjectDifferentiationen_US
dc.subjectProliferationen_US
dc.subjectRepairen_US
dc.titleInvestigation of the effect of ghrelin on bone fracture healing in ratsen_US
dc.typeArticleen_US

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