Thiol/disulfide homeostasis and oxidant status in children with congenital heart disease

Basit Öğe Kaydı
dc.contributor.authorDuymaz, Tomris
dc.date.accessioned2022-10-19T10:18:30Z
dc.date.available2022-10-19T10:18:30Z
dc.date.issued2022-06
dc.description.abstractAbstract: Objectives: This article aims to explain the altered oxidative status and thiol/disulfide homeostasis before and after surgery in children with congenital heart disease (CHD). Methods: Blood samples were taken from the patients (n=50) before the operation (baseline), at the 1st hour, and at the 24th hour after the operation. Thiol-disulfide levels, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), myeloperoxidase (MPO), ceruloplasmin, albumin, ischemia-modified albumin (IMA), and prolidase activities of all samples were measured. Preoperative oxygen saturation (SaO2) values and neutrophil/ lymphocyte ratios (NLR) were also measured. Results: Before the operation, TOS, OSI, MPO, ceruloplasmin, IMA, NRL, and disulfide levels were higher in the cyanotic group than in the acyanotic group. When the indicated three different time points were compared, the TOS, OSI levels, and MPO activities of the 24th hour were significantly lower than the baseline and 1st hour. In comparison, ceruloplasmin levels of 1st hour were significantly higher than of the baseline and 24th hour. Native thiol and total thiol levels in the baseline group were significantly lower than in the 1st and 24th hours. Disulfide levels of the 24th hour were significantly lower than of the baseline. Conclusions: The operation leads to changes in the thiol-disulfide balance and oxidant status in CHD. © 2021 Ibrahim Sogut et al., published by De Gruyter.en_US
dc.fullTextLevelFull Texten_US
dc.identifier.doi10.1515/tjb-2021-0172
dc.identifier.issn0250-4685
dc.identifier.scopus2-s2.0-85135244313en_US
dc.identifier.trdizinid1166682en_US
dc.identifier.urihttps://hdl.handle.net/11411/4593
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0172
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1166682en_US
dc.identifier.wosWOS:000734474100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.issue3en_US
dc.language.isoenen_US
dc.nationalInternationalen_US
dc.numberofauthors6en_US
dc.pages257 - 265en_US
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofTurkish Journal of Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectceruloplasminen_US
dc.subjectcongenital heart surgeryen_US
dc.subjectdisulfideen_US
dc.subjectischemia modified albuminen_US
dc.subjectmyeloperoxidase (MPO)en_US
dc.subjectoxidative stressen_US
dc.titleThiol/disulfide homeostasis and oxidant status in children with congenital heart disease
dc.typeArticle
dc.volume47en_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Duymaz2022.pdf
Boyut:
1.63 MB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Faculty of Health Sciences
Scopus Indexed Publications
TR Dizin Indexed Publications
Web of Science Indexed Publications