Detecting gene interactions within a Bayesian Network framework using external knowledge
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Biological and clinical databases are increasing at a very high rate making a large volume of experimental data publicly available. In this paper, we propose a framework that makes use of external biological knowledge to predict if two given genes interact with each other. To this end, we utilize prior knowledge about interaction of two genes by generating a Bayesian Network using existing external biological knowledge. External knowledge types to be utilized are obtained from interaction databases such as BioGrid and Reac-tome and consist of protein-protein, protein-DNA/RNA, and gene interactions. We first built a naïve Bayesian Network to predict if two genes interact by employing parameter learning using known gene interactions. We propose that the resulting model will be incorporated into methods learning networks from high throughput biological data and interacting genes will be represented in the form of a network. In this process of network generation, the Bayesian Network model deducing gene interactions from external knowledge will be used to calculate the probability of candidate networks to enhance the structure learning task. Our simulations on both synthetic and real data sets show that proposed framework can successfully enhance identification of the true network and be used in predicting gene interactions. © 2012 IEEE.
Açıklama
Middle East Technical University (METU);Inst. Electr. Electron. Eng. (IEEE) Eng. Med. Biol. Soc. (EMBS);TUBITAK;British Council;AKGUN Yazilim
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012 -- 19 April 2012 through 22 April 2012 -- Cappadocia -- 90667
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012 -- 19 April 2012 through 22 April 2012 -- Cappadocia -- 90667
Anahtar Kelimeler
Bayesian Network Models, Biogrid, Biological Data, Candidate Network, Clinical Database, Experimental Data, External Knowledge, Gene İnteractions, High Rate, High Throughput, Interacting Genes, Interaction Database, Learning Network, Network Generation, Parameter Learning, Prior Knowledge, Structure-Learning, Synthetic And Real Data, Bioinformatics, Computer Simulation, Forecasting, Genes, Proteins, Bayesian Networks
Kaynak
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012
WoS Q Değeri
Scopus Q Değeri
N/A
