Graphene oxide reinforced doped dicalcium phosphate bone cements for bone tissue regenerations
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Artificial bone cements have widespread applications in orthopedic and dental surgeries. Nevertheless, there is a need to develop novel materials for artificial bone cements due to limitations like short-service life, weak interaction and attachment with living hard tissue, and the inability to facilitate bone regeneration of calcified tissues rather than replacing them. In the present research, a novel combination of lanthanum (La3+) ions doped dicalcium phosphate (DCP) (La-DCP) and 1.5-3.5 wt.% of graphene oxide (GO) doped La-DCP bone cement materials were successfully synthesized and reported for the first time. Acid/base interaction between La-beta-tricalcium phosphate (La-beta TCP) and monocalcium phosphate monohydrate (MCPM) in the presence of water was the basis for making the La-DCP cements. The synthesized cements were characterized using the XRD, FTIR, FESEM, UV-Vis and TGA techniques. Produced material had La-DCP as in the monetite phase, and La-DCP particles were formed in agglomerates of irregular shapes. The presence of GO enhanced the growth rate of monetite particles, significantly decreased the setting time of the La-DCP bone cement, enhanced mechanical properties and enhanced the adsorption capacity of La-DCP. In vitro studies showed that synthesized GO/La-DCP bone cements were biocompatible, and the proliferation and differentiation properties of human osteosarcoma (Saos-2) cells were significantly improved with the addition of GO. In summary, the synthesized GO/La-DCP bone cement materials, which exhibit good biocompatibility and mechanical properties, have the potential to be employed in bone defect healing.
Açıklama
Anahtar Kelimeler
Dicalcium Phosphate, Lanthanum, Graphene Oxide, Mechanical Properties, Biological Properties, Mechanical-Properties, Phase-Transformation, Protein Adsorption, Hydroxyapatite, Lanthanum, Brushite, Mineralization, Composite, Biocompatibility, Monetite
Kaynak
Journal of The Australian Ceramic Society
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
58
Sayı
5
