PLASMA COENZYME Q10 LEVELS OF INDIVIDUALS WITH NEWLY DIAGNOSED TYPE 2 DIABETES AND DIABETES INDIVIDUALS WITH ADVANCED MICROALBUMINURIA: A COMPARATIVE STUDY

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dc.authorid0000-0002-0659-3586
dc.contributor.authorYildirim, Osman
dc.contributor.authorDemirel, Birsen
dc.contributor.authorGuendogan, Erdal
dc.contributor.authorAvuk, Hande Seven
dc.date.accessioned2026-04-04T18:56:12Z
dc.date.available2026-04-04T18:56:12Z
dc.date.issued2024
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractObjective: Diabetes is a chronic disease that causes the development of microalbuminuria. CoQ10 deficiency is common in people with type 2 diabetes. This study aims to evaluate whether coenzyme Q10 (CoQ10) levels are a risk factor for diabetes and microalbuminuria in newly diagnosed diabetes and advanced microalbuminuria. Material and Method: The study was conducted with patients who came to the internal medicine outpatient clinic. Plasma CoQ10 and malondialdehyde (MDA) values of 90 people in total, including 30 people in each group, newly diagnosed Type 2 diabetes (Group D), diabetes mellitus with microalbuminuria (Group M), and the control group (Group C) were examined. Results: There was no difference between plasma CoQ10 and MDA levels of newly diagnosed type 2 diabetes patients and those with microalbuminuria (p>0.05). There was a negative correlation between CoQ10 and fasting glucose and HbA1c in all groups (p<0.05). A positive correlation was observed between CoQ10 and MDA (p<0.05). CoQ10 level of the control group was found to be higher than Group D and M (p<0.05); the difference between Group M and Group D was not significant (p>0.05). As a result of regression analysis, increasing the CoQ10 value was found to have a protective effect on the risk of diabetes (95 %CI: p=0.005). Conclusion: This study showed that individuals with low blood sugar and HbA1c had high CoQ10 levels. We think that CoQ10 can be considered a risk factor for diabetes, and further studies examining total CoQ10 and ubiquinol/ ubiquinone ratio would be beneficial.
dc.description.sponsorshipAcknowledgments We thank the nurses working in the blood collection laboratory. Osman Yldrm, Birsen Demirel and Hande Seven Avuk contributed equally to this work.
dc.identifier.endpage92
dc.identifier.issn1305-2381
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85203492808
dc.identifier.scopusqualityQ4
dc.identifier.startpage85
dc.identifier.urihttps://hdl.handle.net/11411/10745
dc.identifier.volume20
dc.identifier.wosWOS:001314087400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNobel Ilac
dc.relation.ispartofNobel Medicus
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectCoenzyme Q10
dc.subjectMalondialdehyde
dc.subjectMicroalbuminuria
dc.subjectOxidative Stress
dc.subjectType 2 Diabetes
dc.titlePLASMA COENZYME Q10 LEVELS OF INDIVIDUALS WITH NEWLY DIAGNOSED TYPE 2 DIABETES AND DIABETES INDIVIDUALS WITH ADVANCED MICROALBUMINURIA: A COMPARATIVE STUDY
dc.typeArticle

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