Metformin decreases testicular damages following ischaemia/reperfusion injury in rats

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dc.authoridOrdueri, Nazli Ece/0000-0003-1868-4140|Saribal, Devrim/0000-0003-3301-3708|Karakus, Cemil/0000-0003-3389-7662
dc.authorwosidOrdueri, Nazli Ece/AAN-1714-2021
dc.authorwosidSaribal, Devrim/W-8527-2018
dc.contributor.authorSaribal, Devrim
dc.contributor.authorErdem, Erkan
dc.contributor.authorGungor-Ordueri, Nazli Ece
dc.contributor.authorUsta, Akin
dc.contributor.authorKarakus, Cemil
dc.contributor.authorKaracan, Meric
dc.date.accessioned2024-07-18T20:47:29Z
dc.date.available2024-07-18T20:47:29Z
dc.date.issued2020
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractThe effects of metformin on a testicular torsion injury in adolescent rat testis after I/R were evaluated in the present study. Forty adolescent rats were divided into five groups with eight rats per group: a control group; a sham-operated group; an ischaemia group, where torsion was applied for 4 hr and testis was examined immediately after detorsion; an I/R group, where torsion was applied for 4 hr and the testis was examined 4 hr after detorsion; and an I/R + M group, where the metformin (300 mg/kg) administration was added to the identical procedures used for the I/R group. Spermatogenesis, basal membrane integrity and cleaved caspase-3 expression were assessed. The I/R + M group had a significantly higher Johnsen score than the I/R group (7.9 +/- 0.1 vs. 7.5 +/- 0.2; p F-value = 14.2). Failure of basal membrane integrity was highest in the ischaemia group (45 +/- 5) compared to the other groups (control group, 20 +/- 5; sham-operated group, 16.6 +/- 2.8), but not different between the I/R + M (31.6 +/- 12.5) and the I/R groups (25 +/- 3.5). Cleaved caspase-3 expression was highest in the ischaemia group (73.5 +/- 0.7), and significantly lower in the I/R + M group (33.4 +/- 0.9) than the I/R group (58.5 +/- 0.2; p F-value = 7.6). Metformin decreases testicular damage by exerting protection against the harmful effects of I/R on spermatogenesis and alleviating apoptosis in adolescent rat testis.en_US
dc.identifier.doi10.1111/and.13481
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue2en_US
dc.identifier.pmid31815318en_US
dc.identifier.scopus2-s2.0-85076223218en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13481
dc.identifier.urihttps://hdl.handle.net/11411/7813
dc.identifier.volume52en_US
dc.identifier.wosWOS:000501357500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectCleaved Caspase-3en_US
dc.subjectMetforminen_US
dc.subjectTesticular İschaemiaen_US
dc.subjectReperfusionen_US
dc.subjectTorsionen_US
dc.subjectDetorsionen_US
dc.subjectActivated Protein-Kinaseen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectTorsion-Detorsion Injuryen_US
dc.subjectCell-Specific Apoptosisen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectTissueen_US
dc.subjectAmpken_US
dc.titleMetformin decreases testicular damages following ischaemia/reperfusion injury in rats
dc.typeArticle

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